IKZF3 (IKAROS family zinc finger 3)

2007-02-01   Dessen P  

Identity

HGNC
IKZF3
LOCATION
17q12
LOCUSID
22806
ALIAS
AIO,AIOLOS,ZNFN1A3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22806
MIM: 606221
HGNC: 13178
Ensembl: ENSG00000161405

Variants:

dbSNP: 22806
ClinVar: 22806
TCGA: ENSG00000161405
COSMIC: IKZF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161405ENST00000293068Q9UKT9
ENSG00000161405ENST00000346243Q9UKT9
ENSG00000161405ENST00000346872Q9UKT9
ENSG00000161405ENST00000348427A0A0C4DGN9
ENSG00000161405ENST00000350532Q9UKT9
ENSG00000161405ENST00000351680Q9UKT9
ENSG00000161405ENST00000377944Q9UKT9
ENSG00000161405ENST00000377945Q9UKT9
ENSG00000161405ENST00000377952Q9UKT9
ENSG00000161405ENST00000377958Q9UKT9
ENSG00000161405ENST00000394189Q9UKT9
ENSG00000161405ENST00000439016Q9UKT9
ENSG00000161405ENST00000439167Q9UKT9
ENSG00000161405ENST00000467757Q9UKT9
ENSG00000161405ENST00000535189Q9UKT9
ENSG00000161405ENST00000583368Q9UKT9
ENSG00000161405ENST00000623724Q9UKT9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380156192024Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains.1
380184482024IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children.0
381935702024Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations.1
380156192024Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains.1
380184482024IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children.0
381935702024Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations.1
369300792023IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis.1
369300792023IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis.1
346877902022IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors.13
354446532022AIOLOS Variants Causing Immunodeficiency in Human and Mice.3
361806002022IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target.1
346877902022IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors.13
354446532022AIOLOS Variants Causing Immunodeficiency in Human and Mice.3
361806002022IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target.1
334993142021Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.10

Citation

Dessen P

IKZF3 (IKAROS family zinc finger 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46122/ikzf3-(ikaros-family-zinc-finger-3)