Identity
HGNC
LOCATION
2p24.1
LOCUSID
ALIAS
FCHL2,FLDB,LDLCQ4,apoB-100,apoB-48
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 338
MIM: 107730
HGNC: 603
Ensembl: ENSG00000084674
Variants:
dbSNP: 338
ClinVar: 338
TCGA: ENSG00000084674
COSMIC: APOB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000084674 | ENST00000233242 | P04114 |
| ENSG00000084674 | ENST00000399256 | A8MUN2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164742099 | MTTP | Gene | Pathway | associated | |||
| PA166114922 | lomitapide | Chemical | LabelAnnotation | associated | |||
| PA166114942 | familial hypercholesterolemia | Disease | DataAnnotation, Literature, MultilinkAnnotation | associated | 23788249 | ||
| PA166123431 | heart valve replacement | Disease | ClinicalAnnotation | associated | PD | ||
| PA227 | LDLR | Gene | DataAnnotation | associated | |||
| PA38617 | PCSK9 | Gene | DataAnnotation | associated | |||
| PA444417 | Hemorrhage | Disease | ClinicalAnnotation | associated | PD | ||
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PK | PD | |
| PA446120 | Hypertriglyceridemia | Disease | ClinicalAnnotation | associated | PD | ||
| PA446479 | Hypertrophy, Left Ventricular | Disease | ClinicalAnnotation | associated | PD | 15614026 | |
| PA449594 | fenofibrate | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450084 | irbesartan | Chemical | ClinicalAnnotation | associated | PK | PD | 15614026 |
| PA451906 | warfarin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37410210 | 2024 | Mass-spectrometric analysis of APOB polymorphism rs1042031 (G/T) and its influence on serum proteome of coronary artery disease patients: genetic-derived proteomics consequences. | 0 |
| 37593849 | 2024 | Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris. | 3 |
| 38042210 | 2024 | Association of APO B gene polymorphisms with the development of myocardial infarction in Pakistani population. | 0 |
| 38102060 | 2024 | The relationship between genetic liver fat and coronary heart disease is explained by apoB-containing lipoproteins. | 0 |
| 38292140 | 2024 | ApoA1, ApoB, ApoA1/B for Pathogenic Prediction of Chronic Obstructive Pulmonary Disease Complicated by Acute Lower Respiratory Tract Infection: A Cross-Sectional Study. | 0 |
| 38435750 | 2024 | Analysis of the association between testosterone and cardiovascular disease potential risk factor apolipoprotein B in adult males without cancer: national health and nutrition examination survey 2011-2016. | 0 |
| 38828596 | 2024 | Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis. | 0 |
| 38950110 | 2024 | Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice. | 0 |
| 37410210 | 2024 | Mass-spectrometric analysis of APOB polymorphism rs1042031 (G/T) and its influence on serum proteome of coronary artery disease patients: genetic-derived proteomics consequences. | 0 |
| 37593849 | 2024 | Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris. | 3 |
| 38042210 | 2024 | Association of APO B gene polymorphisms with the development of myocardial infarction in Pakistani population. | 0 |
| 38102060 | 2024 | The relationship between genetic liver fat and coronary heart disease is explained by apoB-containing lipoproteins. | 0 |
| 38292140 | 2024 | ApoA1, ApoB, ApoA1/B for Pathogenic Prediction of Chronic Obstructive Pulmonary Disease Complicated by Acute Lower Respiratory Tract Infection: A Cross-Sectional Study. | 0 |
| 38435750 | 2024 | Analysis of the association between testosterone and cardiovascular disease potential risk factor apolipoprotein B in adult males without cancer: national health and nutrition examination survey 2011-2016. | 0 |
| 38828596 | 2024 | Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis. | 0 |
Citation
Dessen P
APOB (apolipoprotein B)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46136/apob-(apolipoprotein-b)
