Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3105
MIM: 142800
HGNC: 4931
Ensembl: ENSG00000206503
Variants:
dbSNP: 3105
ClinVar: 3105
TCGA: ENSG00000206503
COSMIC: HLA-A
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA153561371 | egfr inhibitors | Chemical | VariantAnnotation | ambiguous | PD | 23057547 | |
| PA162316739 | Maculopapular Exanthema | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21149285, 21917426, 22211527, 22348435, 23132554, 23830818, 24268988, 24322785, 24336023, 24897291, 25495410, 27666425, 27888155, 28340402, 29238301, 29610831 | |
| PA164742987 | clavulanate | Chemical | VariantAnnotation | associated | PD | ||
| PA164745461 | bacampicillin | Chemical | VariantAnnotation | associated | PD | 9609616 | |
| PA164749390 | peginterferon alfa-2a | Chemical | VariantAnnotation | associated | PD | 23360626 | |
| PA164784024 | peginterferon alfa-2b | Chemical | VariantAnnotation | associated | PD | 23360626 | |
| PA164925725 | Toxic liver disease | Disease | VariantAnnotation | associated | PD | 17339877 | |
| PA165108357 | Erythema multiforme NOS | Disease | VariantAnnotation | associated | PD | 29610831 | |
| PA165954030 | HLA-A*31:01:02 | Haplotype | LabelAnnotation | associated | |||
| PA166048814 | Hyperuricemia | Disease | VariantAnnotation | not associated | PD | 23669020 | |
| PA166119041 | drug-induced liver injury | Disease | VariantAnnotation | associated | PD | ||
| PA166120927 | drug reaction with eosinophilia and systemic symptoms | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 21149285, 21917426, 22211527, 22348435, 23132554, 24268988, 24322785, 24336023, 24897291, 25495410, 27888155, 28340402, 29610167, 29610831, 32439433 | |
| PA166120928 | erythema exudativum multiforme | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 22211527, 23669020, 27888155 | |
| PA166120929 | severe cutaneous adverse reactions | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 19668019, 20504258, 21149285, 21244392, 21301380, 21393610, 21912425, 21917426, 22348435, 23669020, 24268988, 24322785, 24336023, 24399721, 27888155 | |
| PA166123207 | overall survival | Disease | VariantAnnotation | not associated | PD | 23057547 | |
| PA166123427 | HLA-A*02:01 | Haplotype | LabelAnnotation | associated | |||
| PA166151827 | adverse events | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 30020991 | |
| PA166182718 | ipilimumab | Chemical | LabelAnnotation | associated | |||
| PA443936 | Drug Hypersensitivity | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 15743917, 17587850, 21149285, 21301380, 21393610, 21545408, 21912425, 21917426, 22211527, 22348435, 23132554, 23669020, 23830818, 24268988, 24322785, 24336023, 24897291, 25495410, 27749688, 27888155, 28340402, 29233746, 29610831 | |
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | associated | PD | 22211527 | |
| PA444059 | Epidermal Necrolysis, Toxic | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21149285, 21545408, 21917426, 22211527, 22348435, 23132554, 24236482, 24268988, 24322785, 24336023, 24897291, 25495410, 27888155, 28340402, 28570299, 29610831 | |
| PA444065 | Epilepsy | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 24399721, 27666425, 28340402, 29610831, 30020991 | |
| PA444109 | Exanthema | Disease | VariantAnnotation | ambiguous | PD | 19104471, 21393610, 23057547, 28340402 | |
| PA444445 | Hepatitis C | Disease | VariantAnnotation | associated | PD | 23360626 | |
| PA444546 | Hypersensitivity | Disease | VariantAnnotation | associated | PD | 29610831 | |
| PA444547 | Hypersensitivity, Delayed | Disease | VariantAnnotation | associated | PD | 9609616 | |
| PA444684 | Kidney Failure, Chronic | Disease | VariantAnnotation | ambiguous | PD | 21393610 | |
| PA445062 | Neoplasms | Disease | VariantAnnotation | ambiguous | PD | 23057547 | |
| PA445096 | Neuralgia | Disease | VariantAnnotation | associated | PD | 29610831 | |
| PA445738 | Stevens-Johnson Syndrome | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 15743917, 17587850, 21149285, 21301380, 21393610, 21545408, 21912425, 21917426, 22211527, 22348435, 23132554, 23669020, 24236482, 24268988, 24322785, 24336023, 24897291, 25495410, 27888155, 28340402, 28570299, 29610831 | |
| PA447199 | Bipolar Disorder | Disease | VariantAnnotation | associated | PD | 29610831 | |
| PA447216 | Schizophrenia | Disease | VariantAnnotation | associated | PD | 29610831 | |
| PA447230 | HIV | Disease | VariantAnnotation | not associated | PD | 19104471 | |
| PA448015 | acetaminophen | Chemical | VariantAnnotation | not associated | PD | 21545408 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 15743917, 17587850, 21301380, 21393610, 21545408, 21912425, 23669020 | |
| PA448406 | amoxicillin | Chemical | VariantAnnotation | associated | PD | 9609616 | |
| PA448419 | ampicillin | Chemical | VariantAnnotation | associated | PD | 9609616 | |
| PA448785 | carbamazepine | Chemical | ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation | ambiguous | PD | 21149285, 21244392, 21917426, 22211527, 22348435, 23132554, 23830818, 24268988, 24322785, 24336023, 24399721, 24897291, 25495410, 27888155, 28340402, 28570299, 29610831 | |
| PA449211 | dapsone | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 29233746 | |
| PA449594 | fenofibrate | Chemical | VariantAnnotation | associated | PD | ||
| PA450164 | lamotrigine | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 19668019, 23830818, 25495410, 29238301 | |
| PA450206 | levetiracetam | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 30020991 | |
| PA450413 | methazolamide | Chemical | VariantAnnotation | not associated | PD | 20504258 | |
| PA450616 | nevirapine | Chemical | VariantAnnotation | not associated | PD | 19104471 | |
| PA450732 | oxcarbazepine | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 27666425, 29610167 | |
| PA450911 | phenobarbital | Chemical | VariantAnnotation | not associated | PD | 24236482 | |
| PA450947 | phenytoin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 27888155 | |
| PA451241 | ribavirin | Chemical | VariantAnnotation | associated | PD | 23360626 | |
| PA451333 | sertraline | Chemical | VariantAnnotation | associated | PD | ||
| PA451614 | terbinafine | Chemical | VariantAnnotation | associated | PD | ||
| PA451632 | tetanus antitoxin | Chemical | VariantAnnotation | associated | PD | 27749688 | |
| PA451686 | ticlopidine | Chemical | VariantAnnotation | associated | PD | 17339877 | |
| PA451850 | vancomycin | Chemical | ClinicalAnnotation | associated | PD | 32439433 | |
| PA451978 | zonisamide | Chemical | ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation | associated | PD | 24236482 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38326406 | 2024 | Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape. | 0 |
| 38946372 | 2024 | [Genetic study of a rare Chinese pedigree with a recombination occurring between the HLA-A/C loci in both parents]. | 0 |
| 38326406 | 2024 | Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape. | 0 |
| 38946372 | 2024 | [Genetic study of a rare Chinese pedigree with a recombination occurring between the HLA-A/C loci in both parents]. | 0 |
| 36180967 | 2023 | Identification of the novel HLA-A*11:01:115 allele, detected in two unrelated bone marrow donors. | 0 |
| 36274646 | 2023 | Identification of three novel HLA class I alleles: HLA-A*02:1008, -A*24:553 and -C*12:350. | 0 |
| 36278730 | 2023 | The identification of three novel HLA-A alleles: HLA-A*03:390:02, -A*26:112:02 and -A*26:221. | 0 |
| 36305175 | 2023 | Two novel HLA class I alleles HLA-A*03:409 and -B*49:72 and the extension of the -B*40:19 allele sequence. | 0 |
| 36437414 | 2023 | Differential HLA class I subunit (A, B, C heavy chain and β(2)-microglobulin) expression levels in normal tissues. | 0 |
| 36595060 | 2023 | The impact of HLA polymorphism on herpesvirus infection and disease. | 1 |
| 36999362 | 2023 | Description of two new HLA alleles, HLA-A*26:01:70 and HLA-A*26:01:74 in Chinese individuals. | 0 |
| 37016751 | 2023 | Characterization of the novel HLA-A*33 allele, HLA-A*33:03:55 in a Chinese individual. | 0 |
| 37246469 | 2023 | Frequency changes in HLA-I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD-L1 expression. | 1 |
| 37417317 | 2023 | Human Leukocyte Antigen Polymorphism HLA-A*24:02 is Associated with Acute Liver Disease in HBV-Infected Han Chinese Adults. | 0 |
| 37485595 | 2023 | HLA-A*02:06 allele may be susceptible to myelodysplastic syndrome in Zhejiang Han population, China. | 0 |
Citation
Dessen P
HLA-A (major histocompatibility complex, class I, A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46138/hla-a-(major-histocompatibility-complex-class-i-a)
