BDKRB1 (bradykinin receptor B1)

2007-02-01

Identity

HGNC

BDKRB1

LOCATION

14q32.2

LOCUSID

623

ALIAS

B1BKR,B1R,BKB1R,BKR1,BRADYB1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 623
MIM: 600337
HGNC: 1029
Ensembl: ENSG00000100739

Variants:

dbSNP: 623
ClinVar: 623
TCGA: ENSG00000100739
COSMIC: BDKRB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100739	ENST00000216629	P46663
ENSG00000100739	ENST00000553356	G3V4Y2
ENSG00000100739	ENST00000611804	P46663

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Calcium signaling pathway	KEGG	hsa04020
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
GPCR downstream signaling	REACTOME	R-HSA-388396
GPCR ligand binding	REACTOME	R-HSA-500792

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated		PD	20712529
PA450877	perindopril	Chemical	ClinicalAnnotation	associated		PD	20712529

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References

Pubmed ID	Year	Title	Citations
30132865	2019	Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.	0
30132865	2019	Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.	0
30366000	2019	Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1.	18
31017477	2019	The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy.	0
31218444	2019	Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.	4
32087235	2020	Kinin B1 receptor: A target for neuroinflammation in hypertension.	17
32087235	2020	Kinin B1 receptor: A target for neuroinflammation in hypertension.	17
33284471	2021	Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.	5
33284471	2021	Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.	5
36142237	2022	The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.	1

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Citation

Dessen P

BDKRB1 (bradykinin receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46143/bdkrb1-(bradykinin-receptor-b1)