F10 (coagulation factor X)

2007-02-01  

Identity

HGNC
F10
LOCATION
13q34
LOCUSID
2159
ALIAS
FX,FXA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2159
MIM: 613872
HGNC: 3528
Ensembl: ENSG00000126218

Variants:

dbSNP: 2159
ClinVar: 2159
TCGA: ENSG00000126218
COSMIC: F10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126218ENST00000375551Q5JVE8
ENSG00000126218ENST00000375559P00742
ENSG00000126218ENST00000375559Q5JVE7
ENSG00000126218ENST00000409306B7ZBK1
ENSG00000126218ENST00000410083F8WBM7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsREACTOMER-HSA-159854
Gamma-carboxylation of protein precursorsREACTOMER-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusREACTOMER-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteinsREACTOMER-HSA-159782
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Extrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140834
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA28660GGCXGenePathwayassociated

References

Pubmed IDYearTitleCitations
370244592023Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection.1
378427942023Five new F10 variants in hereditary factor x deficiency detected by high-throughput sequencing.0
370244592023Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection.1
378427942023Five new F10 variants in hereditary factor x deficiency detected by high-throughput sequencing.0
349273622022The functional role of the autolysis loop in the regulation of factor X upon hemostatic response.1
349952942022Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19.7
364389042022Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa.5
366800952022Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction.1
349273622022The functional role of the autolysis loop in the regulation of factor X upon hemostatic response.1
349952942022Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19.7
364389042022Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa.5
366800952022Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction.1
325995962021A Compound Heterozygosis of Two Novel Mutations Causes Factor X Deficiency in a Chinese Pedigree.1
327625842021Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants.3
343510692021Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case-control study.2

Citation

Dessen P

F10 (coagulation factor X)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46152/f10-(coagulation-factor-x)