Identity
HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
CC-CKR-5,CCCKR5,CCR-5,CD195,CKR-5,CKR5,CMKBR5,IDDM22
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1234
MIM: 601373
HGNC: 1606
Ensembl: ENSG00000160791
Variants:
dbSNP: 1234
ClinVar: 1234
TCGA: ENSG00000160791
COSMIC: CCR5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160791 | ENST00000292303 | P51681 |
| ENSG00000160791 | ENST00000292303 | Q38L21 |
| ENSG00000160791 | ENST00000445772 | P51681 |
| ENSG00000160791 | ENST00000445772 | Q38L21 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164768835 | maraviroc | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37489764 | 2024 | CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia. | 2 |
| 37866719 | 2024 | The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling. | 2 |
| 37962280 | 2024 | CCR5 promoter polymorphisms associated with nonsmall cell lung cancer. | 0 |
| 37984413 | 2024 | CCR5 promoter region polymorphisms in systemic lupus erythematosus. | 0 |
| 38167636 | 2024 | Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions. | 0 |
| 38329228 | 2024 | Higher CCR5 density on CD4 + T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission. | 0 |
| 38507500 | 2024 | JAK/STAT signaling pathway affects CCR5 expression in human CD4(+) T cells. | 1 |
| 38719543 | 2024 | CCR5 and CCL5 in metastatic colorectal cancer. | 0 |
| 38770825 | 2024 | The EBI2 receptor is coexpressed with CCR5 in CD4 + T cells and boosts HIV-1 R5 replication. | 0 |
| 37489764 | 2024 | CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia. | 2 |
| 37866719 | 2024 | The menstrual cycle regulates migratory CD4 T-cell surveillance in the female reproductive tract via CCR5 signaling. | 2 |
| 37962280 | 2024 | CCR5 promoter polymorphisms associated with nonsmall cell lung cancer. | 0 |
| 37984413 | 2024 | CCR5 promoter region polymorphisms in systemic lupus erythematosus. | 0 |
| 38167636 | 2024 | Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions. | 0 |
| 38329228 | 2024 | Higher CCR5 density on CD4 + T-cells in mothers and infants is associated with increased risk of in-utero HIV-1 transmission. | 0 |
Citation
Dessen P
CCR5 (C-C motif chemokine receptor 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46155/ccr5-(c-c-motif-chemokine-receptor-5)
