CCR5 (C-C motif chemokine receptor 5)

2007-02-01 Affiliation

Identity

HGNC

CCR5

LOCATION

3p21.31

LOCUSID

1234

ALIAS

CC-CKR-5,CCCKR5,CCR-5,CD195,CKR-5,CKR5,CMKBR5,IDDM22

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1234
MIM: 601373
HGNC: 1606
Ensembl: ENSG00000160791

Variants:

dbSNP: 1234
ClinVar: 1234
TCGA: ENSG00000160791
COSMIC: CCR5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160791	ENST00000292303	P51681
ENSG00000160791	ENST00000292303	Q38L21
ENSG00000160791	ENST00000445772	P51681
ENSG00000160791	ENST00000445772	Q38L21

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Early Phase of HIV Life Cycle	REACTOME	R-HSA-162594
Binding and entry of HIV virion	REACTOME	R-HSA-173107
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Chemokine receptors bind chemokines	REACTOME	R-HSA-380108
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Interleukin-10 signaling	REACTOME	R-HSA-6783783

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164768835	maraviroc	Chemical	LabelAnnotation	associated

References

Pubmed ID	Year	Title	Citations
17901336	2007	Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.	221
19603542	2009	CCR1 and CCR5 promote hepatic fibrosis in mice.	155
19155524	2009	Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.	133
23152559	2012	Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.	118
24927590	2014	Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.	101
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
23235831	2013	CCR5 is a receptor for Staphylococcus aureus leukotoxin ED.	99
11809184	2002	Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study.	89
20453841	2010	A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.	89
22637726	2012	CCR5 antagonist blocks metastasis of basal breast cancer cells.	88

Citation

Dessen P

CCR5 (C-C motif chemokine receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46155/ccr5-(c-c-motif-chemokine-receptor-5)