Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23406
MIM: 606748
HGNC: 18304
Ensembl: ENSG00000103187
Variants:
dbSNP: 23406
ClinVar: 23406
TCGA: ENSG00000103187
COSMIC: COTL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000103187 | ENST00000262428 | Q14019 |
| ENSG00000103187 | ENST00000262428 | A0A384MTY2 |
| ENSG00000103187 | ENST00000564057 | H3BT58 |
| ENSG00000103187 | ENST00000567786 | A0A087WWC7 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28925397 | 2018 | Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. | 11 |
| 28925397 | 2018 | Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. | 11 |
| 27893417 | 2017 | Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression. | 31 |
| 27893417 | 2017 | Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression. | 31 |
| 24454796 | 2014 | Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. | 26 |
| 25034252 | 2014 | Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. | 20 |
| 24454796 | 2014 | Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. | 26 |
| 25034252 | 2014 | Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. | 20 |
| 22373659 | 2012 | Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential. | 11 |
| 22373659 | 2012 | Differential expression of PAI-RBP1, C1orf142, and COTL1 in non-small cell lung cancer cell lines with different tumor metastatic potential. | 11 |
| 21047053 | 2011 | Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1. | 18 |
| 21047053 | 2011 | Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1. | 18 |
| 19307756 | 2009 | Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders. | 11 |
| 19307756 | 2009 | Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders. | 11 |
| 19807693 | 2009 | Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. | 20 |
Citation
Dessen P
COTL1 (coactosin like F-actin binding protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46173/cotl1-(coactosin-like-f-actin-binding-protein-1)
