PLA2G4C (phospholipase A2 group IVC)

2007-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
CPLA2-gamma

Other Information

Locus ID:

NCBI: 8605
MIM: 603602
HGNC: 9037
Ensembl: ENSG00000105499

Variants:

dbSNP: 8605
ClinVar: 8605
TCGA: ENSG00000105499
COSMIC: PLA2G4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105499ENST00000354276Q9UP65
ENSG00000105499ENST00000595161M0QY18
ENSG00000105499ENST00000595487M0R0M8
ENSG00000105499ENST00000596138M0R0F6
ENSG00000105499ENST00000596352M0R1B4
ENSG00000105499ENST00000597713M0R3I9
ENSG00000105499ENST00000598488M0QX83
ENSG00000105499ENST00000599111Q9UP65
ENSG00000105499ENST00000599300M0QZB1
ENSG00000105499ENST00000599921Q9UP65
ENSG00000105499ENST00000599921A0A024QZH0
ENSG00000105499ENST00000601946M0R339

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
MAPK signaling pathwayKEGGko04010
VEGF signaling pathwayKEGGko04370
Fc epsilon RI signaling pathwayKEGGko04664
Long-term depressionKEGGko04730
GnRH signaling pathwayKEGGko04912
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
MAPK signaling pathwayKEGGhsa04010
VEGF signaling pathwayKEGGhsa04370
Fc epsilon RI signaling pathwayKEGGhsa04664
Long-term depressionKEGGhsa04730
GnRH signaling pathwayKEGGhsa04912
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Serotonergic synapseKEGGhsa04726
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Ras signaling pathwayKEGGhsa04014
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Hydrolysis of LPEREACTOMER-HSA-1483152
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Hydrolysis of LPCREACTOMER-HSA-1483115
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
168826682006Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells.47
159084282005The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.39
172132062007Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.25
120399692002Enzymatic properties of human cytosolic phospholipase A(2)gamma.23
204529862010cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.20
123967162002Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma.15
157886762005Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
195011892009Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma).10

Citation

Dessen P

PLA2G4C (phospholipase A2 group IVC)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46175/pla2g4c-(phospholipase-a2-group-ivc)