Identity
HGNC
LOCATION
3q11.1
LOCUSID
ALIAS
PROS,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5627
MIM: 176880
HGNC: 9456
Ensembl: ENSG00000184500
Variants:
dbSNP: 5627
ClinVar: 5627
TCGA: ENSG00000184500
COSMIC: PROS1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165290929 | ethinyl estradiol / norelgestromin | Chemical | LabelAnnotation | associated | |||
| PA165816542 | CYP2C9*1 | Haplotype | LabelAnnotation | associated | |||
| PA165816543 | CYP2C9*2 | Haplotype | LabelAnnotation | associated | |||
| PA165816544 | CYP2C9*3 | Haplotype | LabelAnnotation | associated | |||
| PA166155091 | rs9923231 | Variant | LabelAnnotation | associated | |||
| PA166179849 | avatrombopag | Chemical | LabelAnnotation | associated | |||
| PA166182748 | lusutrombopag | Chemical | LabelAnnotation | associated | |||
| PA166190221 | estradiol / progesterone | Chemical | LabelAnnotation | associated | |||
| PA28660 | GGCX | Gene | Pathway | associated | |||
| PA451906 | warfarin | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37133403 | 2024 | Replication Study of the Association of GAS6 and PROS1 Polymorphisms with Behçet's Disease in a Japanese Population. | 0 |
| 38175252 | 2024 | Analysis of PROS1 mutations and clinical characteristics in three Chinese families with hereditary protein S deficiency. | 0 |
| 37133403 | 2024 | Replication Study of the Association of GAS6 and PROS1 Polymorphisms with Behçet's Disease in a Japanese Population. | 0 |
| 38175252 | 2024 | Analysis of PROS1 mutations and clinical characteristics in three Chinese families with hereditary protein S deficiency. | 0 |
| 37660436 | 2023 | Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation. | 1 |
| 37660436 | 2023 | Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation. | 1 |
| 34939974 | 2022 | Protein S Erlangen: a novel PROS1 gene mutation associated with quantitative protein S deficiency. | 2 |
| 34968852 | 2022 | Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation. | 0 |
| 35124235 | 2022 | Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations. | 11 |
| 35231993 | 2022 | [Clinical manifestations and gene analysis of 18 cases of hereditary protein S deficiency]. | 0 |
| 35879775 | 2022 | LncRNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated low PROS1 expression is an onco-immunological biomarker in low-grade gliomas: a pan-cancer analysis with experimental verification. | 7 |
| 36203174 | 2022 | AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour. | 3 |
| 36494145 | 2022 | Dysregulation of Protein S in COVID-19. | 3 |
| 36567848 | 2022 | Protein C and S levels in patients with Thalassemia intermedia. | 1 |
| 34939974 | 2022 | Protein S Erlangen: a novel PROS1 gene mutation associated with quantitative protein S deficiency. | 2 |
Citation
Dessen P
PROS1 (protein S)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46212/pros1-(protein-s)
