PROS1 (protein S)

2007-02-01 Affiliation

Identity

HGNC

PROS1

LOCATION

3q11.1

LOCUSID

5627

ALIAS

PROS,PS21,PS22,PS23,PS24,PS25,PSA,THPH5,THPH6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5627
MIM: 176880
HGNC: 9456
Ensembl: ENSG00000184500

Variants:

dbSNP: 5627
ClinVar: 5627
TCGA: ENSG00000184500
COSMIC: PROS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184500	ENST00000348974	P07225
ENSG00000184500	ENST00000348974	A0A0S2Z4K3
ENSG00000184500	ENST00000394236	P07225
ENSG00000184500	ENST00000394236	A0A0S2Z4K3
ENSG00000184500	ENST00000407433	G5E9F8
ENSG00000184500	ENST00000472684	C9K0R0
ENSG00000184500	ENST00000647936	A0A3B3IRK9
ENSG00000184500	ENST00000648853	A0A3B3ISJ1
ENSG00000184500	ENST00000649103	A0A3B3ITZ7
ENSG00000184500	ENST00000649585	A0A3B3IUA6
ENSG00000184500	ENST00000650591	A0A0S2Z4L3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	REACTOME	R-HSA-159854
Gamma-carboxylation of protein precursors	REACTOME	R-HSA-159740
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	REACTOME	R-HSA-159763
Removal of aminoterminal propeptides from gamma-carboxylated proteins	REACTOME	R-HSA-159782
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Complement cascade	REACTOME	R-HSA-166658
Regulation of Complement cascade	REACTOME	R-HSA-977606
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Common Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140875
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA165290929	ethinyl estradiol / norelgestromin	Chemical	LabelAnnotation	associated
PA165816542	CYP2C9*1	Haplotype	LabelAnnotation	associated
PA165816543	CYP2C9*2	Haplotype	LabelAnnotation	associated
PA165816544	CYP2C9*3	Haplotype	LabelAnnotation	associated
PA166155091	rs9923231	Variant	LabelAnnotation	associated
PA166179849	avatrombopag	Chemical	LabelAnnotation	associated
PA166182748	lusutrombopag	Chemical	LabelAnnotation	associated
PA166190221	estradiol / progesterone	Chemical	LabelAnnotation	associated
PA28660	GGCX	Gene	Pathway	associated
PA451906	warfarin	Chemical	LabelAnnotation	associated

References

Pubmed ID	Year	Title	Citations
37133403	2024	Replication Study of the Association of GAS6 and PROS1 Polymorphisms with Behçet's Disease in a Japanese Population.	0
38175252	2024	Analysis of PROS1 mutations and clinical characteristics in three Chinese families with hereditary protein S deficiency.	0
37133403	2024	Replication Study of the Association of GAS6 and PROS1 Polymorphisms with Behçet's Disease in a Japanese Population.	0
38175252	2024	Analysis of PROS1 mutations and clinical characteristics in three Chinese families with hereditary protein S deficiency.	0
37660436	2023	Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.	1
37660436	2023	Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.	1
34939974	2022	Protein S Erlangen: a novel PROS1 gene mutation associated with quantitative protein S deficiency.	2
34968852	2022	Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation.	0
35124235	2022	Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations.	11
35231993	2022	[Clinical manifestations and gene analysis of 18 cases of hereditary protein S deficiency].	0
35879775	2022	LncRNA RP3-525N10.2-NFKB1-PROS1 triplet-mediated low PROS1 expression is an onco-immunological biomarker in low-grade gliomas: a pan-cancer analysis with experimental verification.	7
36203174	2022	AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour.	3
36494145	2022	Dysregulation of Protein S in COVID-19.	3
36567848	2022	Protein C and S levels in patients with Thalassemia intermedia.	1
34939974	2022	Protein S Erlangen: a novel PROS1 gene mutation associated with quantitative protein S deficiency.	2

Citation

Dessen P

PROS1 (protein S)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46212/pros1-(protein-s)