LRRC15 (leucine rich repeat containing 15)

2007-02-01  

Identity

HGNC
LRRC15
LOCATION
3q29
LOCUSID
131578
ALIAS
LIB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 131578
HGNC: 20818
Ensembl: ENSG00000172061

Variants:

dbSNP: 131578
ClinVar: 131578
TCGA: ENSG00000172061
COSMIC: LRRC15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172061ENST00000347624Q8TF66
ENSG00000172061ENST00000428839Q8TF66

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA448499atenololChemicalClinicalAnnotationassociatedPD
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD
PA450480metoprololChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
380516012024Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-β1-Induced PDL Fibroblastic Differentiation.1
385663282024Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis.2
387637742024Effect of LRRC15 on autophagy in A549 cells.0
380516012024Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-β1-Induced PDL Fibroblastic Differentiation.1
385663282024Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis.2
387637742024Effect of LRRC15 on autophagy in A549 cells.0
366253192023RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15.2
367356812023LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.7
367579242023Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.10
366253192023RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15.2
367356812023LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.7
367579242023Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.10
347262552022Cancer‑associated fibroblast‑derived LRRC15 promotes the migration and invasion of triple‑negative breast cancer cells via Wnt/β‑catenin signalling pathway regulation.10
358964922022[Eukaryotic expression and antigen epitope prediction of the LRRC15 protein in excretory secretory antigens of Taenia solium cysticercus].1
362280392022LRRC15 inhibits SARS-CoV-2 cellular entry in trans.8

Citation

Dessen P

LRRC15 (leucine rich repeat containing 15)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46251/lrrc15-(leucine-rich-repeat-containing-15)