PRSS2 (serine protease 2)

2007-02-01  

Identity

HGNC
PRSS2
LOCATION
7q34
LOCUSID
5645
ALIAS
TRY2,TRY8,TRYP2

Other Information

Locus ID:

NCBI: 5645
MIM: 601564
HGNC: 9483
Ensembl: ENSG00000275896

Variants:

dbSNP: 5645
ClinVar: 5645
TCGA: ENSG00000275896
COSMIC: PRSS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275896ENST00000539842P07478
ENSG00000275896ENST00000539842Q5NV56
ENSG00000275896ENST00000632805A6XMV8
ENSG00000275896ENST00000632998A0A0J9YYC8
ENSG00000275896ENST00000633969A6XMV9

Expression (GTEx)

0
10000
20000
30000
40000
50000
60000
70000
80000
90000
100000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DefensinsREACTOMER-HSA-1461973
Alpha-defensinsREACTOMER-HSA-1462054
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361916392023Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.0
370220962023High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer.0
373310892023PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer.1
361916392023Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.0
370220962023High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer.0
373310892023PRSS2 regulates EMT and metastasis via MMP-9 in gastric cancer.1
347941442022TATI, TAT-2, and CRP as Prognostic Factors in Colorectal Cancer.2
350894162022Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.4
365751742022PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.1
347941442022TATI, TAT-2, and CRP as Prognostic Factors in Colorectal Cancer.2
350894162022Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis.4
365751742022PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.1
335155472021Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.13
335155472021Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.13
332029252020Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses.5

Citation

Dessen P

PRSS2 (serine protease 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46254/prss2-(serine-protease-2)