PCBP2 (poly(rC) binding protein 2)

2007-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
HNRNPE2,HNRPE2,hnRNP-E2
FUSION GENES

Other Information

Locus ID:

NCBI: 5094
MIM: 601210
HGNC: 8648
Ensembl: ENSG00000197111

Variants:

dbSNP: 5094
ClinVar: 5094
TCGA: ENSG00000197111
COSMIC: PCBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197111ENST00000359282Q15366
ENSG00000197111ENST00000359462Q15366
ENSG00000197111ENST00000359462A0A384N6B9
ENSG00000197111ENST00000437231Q15366
ENSG00000197111ENST00000439930Q15366
ENSG00000197111ENST00000447282Q15366
ENSG00000197111ENST00000455667Q15366
ENSG00000197111ENST00000546463Q15366
ENSG00000197111ENST00000546652F8W1G6
ENSG00000197111ENST00000547859H3BSS4
ENSG00000197111ENST00000548933Q15366
ENSG00000197111ENST00000549863F8VZX2
ENSG00000197111ENST00000550192F8VTZ0
ENSG00000197111ENST00000550520F8VXH9
ENSG00000197111ENST00000550585H3BND9
ENSG00000197111ENST00000551104F8W0G4
ENSG00000197111ENST00000552296Q15366
ENSG00000197111ENST00000552819Q15366
ENSG00000197111ENST00000552980H3BSP4
ENSG00000197111ENST00000553064F8VRH0
ENSG00000197111ENST00000562264H3BRU6

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385992402024Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.0
387689272024UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.0
385992402024Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.0
387689272024UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.0
375446342023The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.2
378142392023Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.0
379411512023Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.1
375446342023The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2.2
378142392023Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.0
379411512023Binding of microRNA-122 to the hepatitis C virus 5' untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase.1
350896372022PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.6
350896372022PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.6
330370852021PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.8
333136612021PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis.2
342333892021Advances in poly(rC)-binding protein 2: Structure, molecular function, and roles in cancer.12

Citation

Dessen P

PCBP2 (poly(rC) binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46265/pcbp2-(poly(rc)-binding-protein-2)