CAP2 (cyclase associated actin cytoskeleton regulatory protein 2)

2007-02-01  

Identity

HGNC
CAP2
LOCATION
6p22.3
LOCUSID
10486
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10486
MIM: 618385
HGNC: 20039
Ensembl: ENSG00000112186

Variants:

dbSNP: 10486
ClinVar: 10486
TCGA: ENSG00000112186
COSMIC: CAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112186ENST00000229922P40123
ENSG00000112186ENST00000378990E9PDI2
ENSG00000112186ENST00000465994P40123
ENSG00000112186ENST00000476263F8WEW0
ENSG00000112186ENST00000479291F8WDB9
ENSG00000112186ENST00000489374B7Z385
ENSG00000112186ENST00000493172P40123
ENSG00000112186ENST00000611958A0A087WZ15
ENSG00000112186ENST00000616440A0A087X0J3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
170006692006Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis.13
230227742013Involvement of hepatocellular carcinoma biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression.8
263741962015Overexpression of adenylate cyclase-associated protein 2 is a novel prognostic marker in malignant melanoma.8
275736742016Expression status of cyclase‑associated protein 2 as a prognostic marker for human breast cancer.4
305185482019CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.1
316409512019[Association of adenylate cyclase-associated protein 2 expression with histopathology and long-term prognosis of gastric cancer].0
318711992020Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself.0

Citation

Dessen P

CAP2 (cyclase associated actin cytoskeleton regulatory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46267/cap2-(cyclase-associated-actin-cytoskeleton-regulatory-protein-2)