CKB (creatine kinase B)

2007-02-01  

Identity

HGNC
CKB
LOCATION
14q32.33
LOCUSID
1152
ALIAS
B-CK,BCK,CKBB,CPK-B,HEL-211,HEL-S-29
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1152
MIM: 123280
HGNC: 1991
Ensembl: ENSG00000166165

Variants:

dbSNP: 1152
ClinVar: 1152
TCGA: ENSG00000166165
COSMIC: CKB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166165ENST00000348956P12277
ENSG00000166165ENST00000348956V9HWH2
ENSG00000166165ENST00000553610H0YJG0
ENSG00000166165ENST00000553652G3V2I1
ENSG00000166165ENST00000553878G3V4N7
ENSG00000166165ENST00000554989H0YJJ7
ENSG00000166165ENST00000555039H0YJK0
ENSG00000166165ENST00000557530G3V461

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Creatine pathwayKEGGhsa_M00047
Creatine pathwayKEGGM00047
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Creatine metabolismREACTOMER-HSA-71288
Metabolism of polyaminesREACTOMER-HSA-351202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371569122023Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.28
371569122023Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.28
334853122021Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer.3
335977562021Creatine kinase B controls futile creatine cycling in thermogenic fat.62
347063062021CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.8
334853122021Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer.3
335977562021Creatine kinase B controls futile creatine cycling in thermogenic fat.62
347063062021CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.8
283645832017Creatine kinase in human erythrocytes: A genetic anomaly reveals presence of soluble brain-type isoform.1
288067702017Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.14
283645832017Creatine kinase in human erythrocytes: A genetic anomaly reveals presence of soluble brain-type isoform.1
288067702017Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.14
273189912016Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites.31
292270812016Prx II and CKBB proteins interaction under physiologic al and thermal stress conditions in A549 and HeLa cells.0
273189912016Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites.31

Citation

Dessen P

CKB (creatine kinase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46284/ckb-(creatine-kinase-b)