CKB (creatine kinase B)

2007-02-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
B-CK,BCK,CKBB,CPK-B,HEL-211,HEL-S-29
FUSION GENES

Other Information

Locus ID:

NCBI: 1152
MIM: 123280
HGNC: 1991
Ensembl: ENSG00000166165

Variants:

dbSNP: 1152
ClinVar: 1152
TCGA: ENSG00000166165
COSMIC: CKB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166165ENST00000348956P12277
ENSG00000166165ENST00000348956V9HWH2
ENSG00000166165ENST00000553610H0YJG0
ENSG00000166165ENST00000553652G3V2I1
ENSG00000166165ENST00000553878G3V4N7
ENSG00000166165ENST00000554989H0YJJ7
ENSG00000166165ENST00000555039H0YJK0
ENSG00000166165ENST00000557530G3V461

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Creatine pathwayKEGGhsa_M00047
Creatine pathwayKEGGM00047
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Creatine metabolismREACTOMER-HSA-71288
Metabolism of polyaminesREACTOMER-HSA-351202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121609382002Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.135
163849812006Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.64
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
194059532009Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.38
164240072006Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.27
189772272008Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex.21
204601522010Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease.14
213087352011Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.13
185661072008HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.11
205208252010Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter.11

Citation

Dessen P

CKB (creatine kinase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46284/ckb-(creatine-kinase-b)