BDNF (brain derived neurotrophic factor)

2007-02-01  

Identity

HGNC
BDNF
LOCATION
11p14.1
LOCUSID
627
ALIAS
ANON2,BULN2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 627
MIM: 113505
HGNC: 1033
Ensembl: ENSG00000176697

Variants:

dbSNP: 627
ClinVar: 627
TCGA: ENSG00000176697
COSMIC: BDNF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176697ENST00000314915P23560
ENSG00000176697ENST00000356660P23560
ENSG00000176697ENST00000356660A0A0E3SU01
ENSG00000176697ENST00000395978P23560
ENSG00000176697ENST00000395978A0A0E3SU01
ENSG00000176697ENST00000395980P23560
ENSG00000176697ENST00000395980A0A0E3SU01
ENSG00000176697ENST00000395981P23560
ENSG00000176697ENST00000395981A0A0E3SU01
ENSG00000176697ENST00000395983P23560
ENSG00000176697ENST00000395983A0A0E3SU01
ENSG00000176697ENST00000395986P23560
ENSG00000176697ENST00000418212P23560
ENSG00000176697ENST00000418212A0A0E3SU01
ENSG00000176697ENST00000420794P23560
ENSG00000176697ENST00000420794A0A0E3SU01
ENSG00000176697ENST00000438929P23560
ENSG00000176697ENST00000439476P23560
ENSG00000176697ENST00000439476A0A0E3SU01
ENSG00000176697ENST00000525528P23560
ENSG00000176697ENST00000525528A0A0E3SU01
ENSG00000176697ENST00000525950P23560
ENSG00000176697ENST00000525950A0A0E3SU01
ENSG00000176697ENST00000530786E9PMP3
ENSG00000176697ENST00000530861P23560
ENSG00000176697ENST00000530861A0A0E3SU01
ENSG00000176697ENST00000532997P23560
ENSG00000176697ENST00000532997A0A0E3SU01
ENSG00000176697ENST00000533131P23560
ENSG00000176697ENST00000533131A0A0E3SU01
ENSG00000176697ENST00000533246P23560
ENSG00000176697ENST00000533246A0A0E3SU01

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Huntington's diseaseKEGGko05016
MAPK signaling pathwayKEGGhsa04010
Huntington's diseaseKEGGhsa05016
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD19641488
PA128406954Weight gainDiseaseMultilinkAnnotationassociated24279860
PA164712362AnalgesicsChemicalClinicalAnnotationassociated25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociated25096645
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociated25096645
PA164713257Selective serotonin reuptake inhibitorsChemicalLiterature, MultilinkAnnotationassociated24930681
PA166119022methamphetamine dependenceDiseaseClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotation, MultilinkAnnotationassociatedPD23651024, 24279859
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD23651024
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD24279859, 26401760, 28692418
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD16633140, 24595507, 25560300
PA447278DepressionDiseaseClinicalAnnotationassociatedPD
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD19236730, 19641488, 20016225, 21338649, 22965830, 23619509, 29748862
PA449015citalopramChemicalClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA449233desipramineChemicalClinicalAnnotationassociatedPD
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD20016225
PA450243lithiumChemicalLiterature, MultilinkAnnotationassociated24885933
PA450401methadoneChemicalClinicalAnnotationassociatedPD23651024
PA450403methamphetamineChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD24279859, 26401760, 28692418
PA450657nortriptylineChemicalClinicalAnnotationassociatedPD19641488
PA450688olanzapineChemicalClinicalAnnotationassociatedPD24595507
PA450801paroxetineChemicalClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA451566sumatriptanChemicalClinicalAnnotationassociated25096645
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD16633140, 25560300
PA452618opioidsChemicalClinicalAnnotationassociated25096645
PA452619heroinChemicalClinicalAnnotationassociatedPD24279859, 26401760, 28692418

References

Pubmed IDYearTitleCitations
362235492024A pilot study examining BDNF Val66Met polymorphism and biological sex: Relationships with baseline cognitive functioning in adolescent athletes.0
368558162024Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation, and negative emotionality.1
371862752024Effects of a physical exercise or motor activity protocol on cognitive function, lipid profile, and BDNF levels in older adults with mild cognitive impairment.3
374918572024Interaction of Brain-derived Neurotrophic Factor, Exercise, and Fear Extinction: Implications for Post-traumatic Stress Disorder.1
376756252024Human iPSC-derived endothelial cells promote CNS remyelination via BDNF and mTORC1 pathway.0
377062462024Evaluation of the relationship between serum BDNF concentration and indicators of oxidative stress and inflammation in COVID-19 patients with neurological disorders - a pilot study.1
378209582024Influence of BDNF Val66Met genetic polymorphism in Major Depressive Disorder and Body Mass Index: Evidence from a meta-analysis of 6481 individuals.1
378716422024Impact of Strength Training Intensity on Brain-derived Neurotrophic Factor.0
380065772024The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy.3
380082092024TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury.1
380095312024Brain-derived neurotrophic factor (BDNF) downregulates mRNA levels of suppressor of cancer cell invasion (SCAI) variants in cortical neurons.0
380704712024Estrogen, progesterone, cortisol, brain-derived neurotrophic factor, and vascular endothelial growth factor during the luteal phase of the menstrual cycle in women with premenstrual dysphoric disorder.0
381429022024ProBDNF contributed to patrolling monocyte infiltration and renal damage in systemic lupus erythematosus.0
381484272024Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF.0
381645672024Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a Mouse Model.0

Citation

Dessen P

BDNF (brain derived neurotrophic factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46287/bdnf-(brain-derived-neurotrophic-factor)