Identity
HGNC
LOCATION
12p12.2
LOCUSID
ALIAS
HBLRR,LST-2,LST-3TM13,LST3,OATP-8,OATP1B3,OATP8,SLC21A8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 28234
MIM: 605495
HGNC: 10961
Ensembl: ENSG00000111700
Variants:
dbSNP: 28234
ClinVar: 28234
TCGA: ENSG00000111700
COSMIC: SLCO1B3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111700 | ENST00000261196 | Q9NPD5 |
| ENSG00000111700 | ENST00000381545 | Q9NPD5 |
| ENSG00000111700 | ENST00000540853 | F5H8K0 |
| ENSG00000111700 | ENST00000544370 | H0YGG9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133950441 | hmg coa reductase inhibitors | Chemical | Pathway | associated | |||
| PA134308647 | rosuvastatin | Chemical | Pathway | associated | |||
| PA151958383 | Gastrointestinal Stromal Tumors | Disease | ClinicalAnnotation | associated | PD | 28117434 | |
| PA162372840 | sunitinib | Chemical | ClinicalAnnotation | associated | PD | 28117434 | |
| PA164748728 | mycophenolic acid | Chemical | ClinicalAnnotation | associated | PD | ||
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | PD | 17906856, 19890249, 21142914, 21878834 |
| PA166114454 | transplant rejection | Disease | ClinicalAnnotation | associated | PD | ||
| PA166114457 | lung transplantation | Disease | ClinicalAnnotation | associated | PD | ||
| PA166122590 | simeprevir | Chemical | LabelAnnotation | associated | |||
| PA166123207 | overall survival | Disease | ClinicalAnnotation | associated | PD | ||
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated | |||
| PA166163438 | elbasvir / grazoprevir | Chemical | LabelAnnotation | associated | |||
| PA166195784 | chronic lung allograft dysfunction | Disease | ClinicalAnnotation | associated | PD | ||
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 26641474 | |
| PA444818 | Lung Neoplasms | Disease | ClinicalAnnotation | associated | PD | 26267044, 26641474 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 18294295 |
| PA448500 | atorvastatin | Chemical | Pathway | associated | |||
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 26267044, 26641474 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation, Pathway | associated | PK | PD | 18294295, 21151855 |
| PA449688 | fluvastatin | Chemical | Pathway | associated | |||
| PA450272 | lovastatin | Chemical | Pathway | associated | |||
| PA450428 | methotrexate | Chemical | Pathway | associated | 21317831 | ||
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PK | PD | 17906856, 19890249, 21142914, 21878834 |
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation, Pathway | associated | PD | 21151855, 26267044, 26641474 | |
| PA451089 | pravastatin | Chemical | Pathway | associated | 25502615 | ||
| PA451363 | simvastatin | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37856781 | 2024 | SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis. | 0 |
| 38279097 | 2024 | Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population. | 0 |
| 38641828 | 2024 | N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1. | 0 |
| 37856781 | 2024 | SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis. | 0 |
| 38279097 | 2024 | Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population. | 0 |
| 38641828 | 2024 | N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1. | 0 |
| 36964102 | 2023 | SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome. | 1 |
| 36988399 | 2023 | Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer. | 0 |
| 37723174 | 2023 | Structure of human drug transporters OATP1B1 and OATP1B3. | 4 |
| 36964102 | 2023 | SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome. | 1 |
| 36988399 | 2023 | Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer. | 0 |
| 37723174 | 2023 | Structure of human drug transporters OATP1B1 and OATP1B3. | 4 |
| 34354231 | 2022 | Intronic LINE-1 insertion in SLCO1B3 as a highly prevalent cause of rotor syndrome in East Asian population. | 1 |
| 35328066 | 2022 | Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease. | 2 |
| 34354231 | 2022 | Intronic LINE-1 insertion in SLCO1B3 as a highly prevalent cause of rotor syndrome in East Asian population. | 1 |
Citation
Dessen P
SLCO1B3 (solute carrier organic anion transporter family member 1B3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46289/slco1b3-(solute-carrier-organic-anion-transporter-family-member-1b3)
