SLCO1B3 (solute carrier organic anion transporter family member 1B3)

2007-02-01  

Identity

HGNC
LOCATION
12p12.2
LOCUSID
ALIAS
HBLRR,LST-2,LST-3TM13,LST3,OATP-8,OATP1B3,OATP8,SLC21A8
FUSION GENES

Other Information

Locus ID:

NCBI: 28234
MIM: 605495
HGNC: 10961
Ensembl: ENSG00000111700

Variants:

dbSNP: 28234
ClinVar: 28234
TCGA: ENSG00000111700
COSMIC: SLCO1B3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111700ENST00000261196Q9NPD5
ENSG00000111700ENST00000381545Q9NPD5
ENSG00000111700ENST00000540853F5H8K0
ENSG00000111700ENST00000544370H0YGG9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Recycling of bile acids and saltsREACTOMER-HSA-159418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134308647rosuvastatinChemicalPathwayassociated
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD28117434
PA162372840sunitinibChemicalClinicalAnnotationassociatedPD28117434
PA164748728mycophenolic acidChemicalClinicalAnnotationassociatedPD
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD17906856, 19890249, 21142914, 21878834
PA166114454transplant rejectionDiseaseClinicalAnnotationassociatedPD
PA166114457lung transplantationDiseaseClinicalAnnotationassociatedPD
PA166122590simeprevirChemicalLabelAnnotationassociated
PA166123207overall survivalDiseaseClinicalAnnotationassociatedPD
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166163438elbasvir / grazoprevirChemicalLabelAnnotationassociated
PA166195784chronic lung allograft dysfunctionDiseaseClinicalAnnotationassociatedPD
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD26641474
PA444818Lung NeoplasmsDiseaseClinicalAnnotationassociatedPD26267044, 26641474
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD18294295
PA448500atorvastatinChemicalPathwayassociated
PA448803carboplatinChemicalClinicalAnnotationassociatedPD26267044, 26641474
PA449383docetaxelChemicalClinicalAnnotation, PathwayassociatedPKPD18294295, 21151855
PA449688fluvastatinChemicalPathwayassociated
PA450272lovastatinChemicalPathwayassociated
PA450428methotrexateChemicalPathwayassociated21317831
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPKPD17906856, 19890249, 21142914, 21878834
PA450761paclitaxelChemicalClinicalAnnotation, PathwayassociatedPD21151855, 26267044, 26641474
PA451089pravastatinChemicalPathwayassociated25502615
PA451363simvastatinChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
378567812024SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.0
382790972024Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.0
386418282024N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.0
378567812024SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.0
382790972024Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.0
386418282024N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.0
369641022023SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.1
369883992023Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer.0
377231742023Structure of human drug transporters OATP1B1 and OATP1B3.4
369641022023SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.1
369883992023Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer.0
377231742023Structure of human drug transporters OATP1B1 and OATP1B3.4
343542312022Intronic LINE-1 insertion in SLCO1B3 as a highly prevalent cause of rotor syndrome in East Asian population.1
353280662022Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.2
343542312022Intronic LINE-1 insertion in SLCO1B3 as a highly prevalent cause of rotor syndrome in East Asian population.1

Citation

Dessen P

SLCO1B3 (solute carrier organic anion transporter family member 1B3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46289/slco1b3-(solute-carrier-organic-anion-transporter-family-member-1b3)