ARPC2 (actin related protein 2/3 complex subunit 2)

2007-02-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
ARC34,PNAS-139,PRO2446,p34-Arc
FUSION GENES

Other Information

Locus ID:

NCBI: 10109
MIM: 604224
HGNC: 705
Ensembl: ENSG00000163466

Variants:

dbSNP: 10109
ClinVar: 10109
TCGA: ENSG00000163466
COSMIC: ARPC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163466ENST00000295685O15144
ENSG00000163466ENST00000295685Q53R19
ENSG00000163466ENST00000315717O15144
ENSG00000163466ENST00000315717Q53R19
ENSG00000163466ENST00000414983G5E9S7
ENSG00000163466ENST00000420104C9JTV5
ENSG00000163466ENST00000420201G5E9J0
ENSG00000163466ENST00000456575H7C3F9

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188364482008Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.189
188364482008Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.189
157935642005Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.68
219755492011Filopodia initiation: focus on the Arp2/3 complex and formins.60
209748122010Revolving movement of a dynamic cluster of actin filaments during mitosis.31
246215692014Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions.23
203080622010Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.19
221882082012Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway.18
252607532012Analysis of osteoprotegerin (OPG) gene polymorphism in Iranian patients with chronic periodontitis and peri-implantitis. A cross-sectional study.14
152799002004Decreased expression of the seven ARP2/3 complex genes in human gastric cancers.11

Citation

Dessen P

ARPC2 (actin related protein 2/3 complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46295/arpc2-(actin-related-protein-2-3-complex-subunit-2)