SAFB2 (scaffold attachment factor B2)

2007-02-01 Affiliation

Identity

HGNC

SAFB2

LOCATION

19p13.3

LOCUSID

9667

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9667
MIM: 608066
HGNC: 21605
Ensembl: ENSG00000130254

Variants:

dbSNP: 9667
ClinVar: 9667
TCGA: ENSG00000130254
COSMIC: SAFB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130254	ENST00000252542	Q14151
ENSG00000130254	ENST00000590262	K7ERX3
ENSG00000130254	ENST00000591120	Q14151
ENSG00000130254	ENST00000591123	K7EQU4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36652182	2023	SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway via NFAT5.	1
36652182	2023	SAFB2 Inhibits the Progression of Breast Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway via NFAT5.	1
32502422	2020	SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts.	29
32502422	2020	SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts.	29
26273616	2015	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	4
26273616	2015	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	4
22566185	2012	Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.	9
22566185	2012	Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.	9
19137425	2010	Low SAFB levels are associated with worse outcome in breast cancer patients.	19
19901029	2010	SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.	17
19137425	2010	Low SAFB levels are associated with worse outcome in breast cancer patients.	19
19901029	2010	SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.	17
19674106	2009	The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.	9
19674106	2009	The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.	9
19077293	2008	No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.	5

Citation

Dessen P

SAFB2 (scaffold attachment factor B2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46306/safb2-(scaffold-attachment-factor-b2)