P2RY6 (pyrimidinergic receptor P2Y6)

2007-02-01  

Identity

HGNC
P2RY6
LOCATION
11q13.4
LOCUSID
5031
ALIAS
P2Y6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5031
MIM: 602451
HGNC: 8543
Ensembl: ENSG00000171631

Variants:

dbSNP: 5031
ClinVar: 5031
TCGA: ENSG00000171631
COSMIC: P2RY6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171631ENST00000349767Q15077
ENSG00000171631ENST00000349767A0A024R5I9
ENSG00000171631ENST00000393590Q15077
ENSG00000171631ENST00000393590A0A024R5I9
ENSG00000171631ENST00000393591Q15077
ENSG00000171631ENST00000393591A0A024R5I9
ENSG00000171631ENST00000393592Q15077
ENSG00000171631ENST00000393592A0A024R5I9
ENSG00000171631ENST00000535931F5GYF3
ENSG00000171631ENST00000536225F5H7H9
ENSG00000171631ENST00000538328Q15077
ENSG00000171631ENST00000538328A0A024R5I9
ENSG00000171631ENST00000540124Q15077
ENSG00000171631ENST00000540124A0A024R5I9
ENSG00000171631ENST00000540342Q15077
ENSG00000171631ENST00000540342A0A024R5I9
ENSG00000171631ENST00000542092Q15077
ENSG00000171631ENST00000542092A0A024R5I9
ENSG00000171631ENST00000544437F5GX90
ENSG00000171631ENST00000618468Q15077
ENSG00000171631ENST00000618468A0A024R5I9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380364162024Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.0
382256672024Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells.0
382467242024The role of P2Y(6) receptor in the pathogenesis of cardiovascular and inflammatory diseases.0
380364162024Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.0
382256672024Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells.0
382467242024The role of P2Y(6) receptor in the pathogenesis of cardiovascular and inflammatory diseases.0
365654712023P2Y(6) receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging.9
375452272023Pyrimidinergic receptor P2Y6 expression is elevated in lung adenocarcinoma and is associated with poor prognosis.0
378807032023Immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma: a multi-omics studies and single-cell sequencing analysis.1
365654712023P2Y(6) receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging.9
375452272023Pyrimidinergic receptor P2Y6 expression is elevated in lung adenocarcinoma and is associated with poor prognosis.0
378807032023Immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma: a multi-omics studies and single-cell sequencing analysis.1
344265422021Purinergic Receptor P2Y(6) Is a Negative Regulator of NK Cell Maturation and Function.5
344265422021Purinergic Receptor P2Y(6) Is a Negative Regulator of NK Cell Maturation and Function.5
320370852020The expression of the P2Y(6) receptor is regulated at the transcriptional level by p53.3

Citation

Dessen P

P2RY6 (pyrimidinergic receptor P2Y6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46309/p2ry6-(pyrimidinergic-receptor-p2y6)