SP100 (SP100 nuclear antigen)

2007-02-01  

Identity

HGNC
SP100
LOCATION
2q37.1
LOCUSID
6672
ALIAS
lysp100b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6672
MIM: 604585
HGNC: 11206
Ensembl: ENSG00000067066

Variants:

dbSNP: 6672
ClinVar: 6672
TCGA: ENSG00000067066
COSMIC: SP100

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067066ENST00000264052P23497
ENSG00000067066ENST00000340126P23497
ENSG00000067066ENST00000409112P23497
ENSG00000067066ENST00000409341P23497
ENSG00000067066ENST00000409824E9PHV6
ENSG00000067066ENST00000409897P23497
ENSG00000067066ENST00000413284H7C1G8
ENSG00000067066ENST00000427101P23497
ENSG00000067066ENST00000431952H0Y4R8
ENSG00000067066ENST00000432979C9JBL0
ENSG00000067066ENST00000452345H7C4B4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381180022024Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A.2
381180022024Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A.2
353530022022PML Body Component Sp100A Restricts Wild-Type Herpes Simplex Virus 1 Infection.5
353530022022PML Body Component Sp100A Restricts Wild-Type Herpes Simplex Virus 1 Infection.5
308546882019Genome-wide Association Studies of Specific Antinuclear Autoantibody Subphenotypes in Primary Biliary Cholangitis.17
311805312019S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer.17
308546882019Genome-wide Association Studies of Specific Antinuclear Autoantibody Subphenotypes in Primary Biliary Cholangitis.17
311805312019S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer.17
300606042018The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome.10
300606042018The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome.10
284390262017The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments.22
289684432017Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle.18
284390262017The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments.22
289684432017Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle.18
264911692016Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins.27

Citation

Dessen P

SP100 (SP100 nuclear antigen)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46310