Dermcidin (DCD) is a 110-amino acid protein, which is cleaved in several other peptides with different functions. The best-known function of this protein is as antimicrobial host defense, acting majorly in the skin, where many DCD derivatives were identified to be constitutively secreted, mainly by sweat glands. Additionally, Y-P30, one of such derivatives, has been described as a survival factor predominantly in stressed neural cells. This function has also been investigated in cancer cells, portraying DCD as an oncogene, as well a novel biomarker for this disease. Furthermore, PIF, another DCD derivative, may be an important inducer of non-fat weight loss, which has been related with cachexia. The present review assesses data on DCD and derivatives observing DNA, RNA, encoded proteins and their various functions, highlighting their relevance in cancer and other clinical conditions.
NCBI: 117159 MIM: 606634 HGNC: 14669 Ensembl: ENSG00000161634
dbSNP: 117159 ClinVar: 117159 TCGA: ENSG00000161634 COSMIC: DCD
Amanda Soares Hirata ; Rodrigo dos Anjos Miguel ; Paula Christine Jimenez ; Letícia Veras Costa-Lotufo
DCD (dermcidin)
Atlas Genet Cytogenet Oncol Haematol. 2020-07-01
Online version: http://atlasgeneticsoncology.org/gene/46314/dcd-(dermcidin)