CCR3 (C-C motif chemokine receptor 3)

2007-02-01  

Identity

HGNC
CCR3
LOCATION
3p21.31
LOCUSID
1232
ALIAS
C

Other Information

Locus ID:

NCBI: 1232
MIM: 601268
HGNC: 1604
Ensembl: ENSG00000183625

Variants:

dbSNP: 1232
ClinVar: 1232
TCGA: ENSG00000183625
COSMIC: CCR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183625ENST00000357422P51677
ENSG00000183625ENST00000357422A0A024R2Z3
ENSG00000183625ENST00000395940P51677
ENSG00000183625ENST00000395940A0A024R2Z3
ENSG00000183625ENST00000395942P51677
ENSG00000183625ENST00000395942A0A024R2Z3
ENSG00000183625ENST00000452454Q8TDP5
ENSG00000183625ENST00000457243Q8TDP4
ENSG00000183625ENST00000545097P51677

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361233912023CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines.3
361311652023CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation.7
369713312023CD193 (CCR3) expression by B cells correlates with reduced IgE production in paediatric schistosomiasis.0
361233912023CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines.3
361311652023CCL24/CCR3 axis plays a central role in angiotensin II-induced heart failure by stimulating M2 macrophage polarization and fibroblast activation.7
369713312023CD193 (CCR3) expression by B cells correlates with reduced IgE production in paediatric schistosomiasis.0
358092722022The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.0
358092722022The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes on oral aphthous-like lesions in PFAPA syndrome.0
335409822021[Effect of CCR3 gene on related inflammatory cells in respiratory allergic diseases].3
335562952021Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3.15
336714692021The Chemokine Receptor CCR3 Is Potentially Involved in the Homing of Prostate Cancer Cells to Bone: Implication of Bone-Marrow Adipocytes.14
336719562021Stromal CCL5 Promotes Breast Cancer Progression by Interacting with CCR3 in Tumor Cells.13
341842002021CCR3 gene overexpression in patients with Down syndrome.0
335409822021[Effect of CCR3 gene on related inflammatory cells in respiratory allergic diseases].3
335562952021Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3.15

Citation

Dessen P

CCR3 (C-C motif chemokine receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46317/ccr3-(c-c-motif-chemokine-receptor-3)