CMA1 (chymase 1)

2007-02-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
CYH,MCT1,chymase

Other Information

Locus ID:

NCBI: 1215
MIM: 118938
HGNC: 2097
Ensembl: ENSG00000092009

Variants:

dbSNP: 1215
ClinVar: 1215
TCGA: ENSG00000092009
COSMIC: CMA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092009ENST00000206446P23946
ENSG00000092009ENST00000250378P23946

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
221807852011Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue.54
242577552014Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation.39
245071592014Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.36
223638242012Association of mast cell-derived VEGF and proteases in Dengue shock syndrome.34
147018122004Depletion of pre-beta-high density lipoprotein by human chymase impairs ATP-binding cassette transporter A1- but not scavenger receptor class B type I-mediated lipid efflux to high density lipoprotein.24
180794082008Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.24
165204122006Advanced glycation end products activate a chymase-dependent angiotensin II-generating pathway in diabetic complications.18
193322652009Polymorphism in the angiotensin II type 1 receptor (AGTR1) is associated with age at diagnosis in pulmonary arterial hypertension.17
120974092002Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells.16

Citation

Dessen P

CMA1 (chymase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46327/cma1-(chymase-1)