P4HA1 (prolyl 4-hydroxylase subunit alpha 1)

2007-02-01   Dessen P  

Identity

HGNC
P4HA1
LOCATION
10q22.1
LOCUSID
5033
ALIAS
P4HA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5033
MIM: 176710
HGNC: 8546
Ensembl: ENSG00000122884

Variants:

dbSNP: 5033
ClinVar: 5033
TCGA: ENSG00000122884
COSMIC: P4HA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122884ENST00000263556P13674
ENSG00000122884ENST00000263556Q5VSQ6
ENSG00000122884ENST00000307116P13674
ENSG00000122884ENST00000373008P13674
ENSG00000122884ENST00000373008Q5VSQ6
ENSG00000122884ENST00000394890P13674
ENSG00000122884ENST00000440381P13674

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360437662023Prolyl 4-hydroxylase P4HA1 Mediates the Interplay Between Glucose Metabolism and Stemness in Pancreatic Cancer Cells.5
367022902023P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression.4
367345882023P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.1
371611362023Identification and verification of FN1, P4HA1 and CREBBP as potential biomarkers in human atrial fibrillation.0
372479002023P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma.0
379225702023Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.2
381340532023P4HA1 expression and function in esophageal squamous cell carcinoma.0
360437662023Prolyl 4-hydroxylase P4HA1 Mediates the Interplay Between Glucose Metabolism and Stemness in Pancreatic Cancer Cells.5
367022902023P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression.4
367345882023P4HA1, transcriptionally activated by STAT1, promotes esophageal cancer progression.1
371611362023Identification and verification of FN1, P4HA1 and CREBBP as potential biomarkers in human atrial fibrillation.0
372479002023P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma.0
379225702023Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.2
381340532023P4HA1 expression and function in esophageal squamous cell carcinoma.0
343871182021Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.3

Citation

Dessen P

P4HA1 (prolyl 4-hydroxylase subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46330/p4ha1-(prolyl-4-hydroxylase-subunit-alpha-1)