SOX6 (SRY-box transcription factor 6)

2007-02-01  

Identity

HGNC
SOX6
LOCATION
11p15.2
LOCUSID
55553
ALIAS
HSSOX6,SOXD,TOLCAS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55553
MIM: 607257
HGNC: 16421
Ensembl: ENSG00000110693

Variants:

dbSNP: 55553
ClinVar: 55553
TCGA: ENSG00000110693
COSMIC: SOX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110693ENST00000316399P35712
ENSG00000110693ENST00000396356P35712
ENSG00000110693ENST00000526673E9PN02
ENSG00000110693ENST00000527619P35712
ENSG00000110693ENST00000528252P35712
ENSG00000110693ENST00000528429P35712
ENSG00000110693ENST00000529469E9PQ67
ENSG00000110693ENST00000530378E9PQ78
ENSG00000110693ENST00000533411E9PQL4
ENSG00000110693ENST00000655819P35712

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383838422024MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.0
387044542024Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6.0
388481632024LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis.1
383838422024MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.0
387044542024Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6.0
388481632024LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis.1
361171902023Clinical implications and genetical insights of SOX6 expression in acute myeloid leukemia.0
363694282023MiR-19b-3p Inhibits Hypoxia-Ischemia Encephalopathy by Inhibiting SOX6 Expression via Activating Wnt/β-catenin Pathway.2
367053032023Circ_0001498 contributes to lipopolysaccharide-induced lung cell apoptosis and inflammation in sepsis-related acute lung injury via upregulating SOX6 by interacting with miR-574-5p.3
361171902023Clinical implications and genetical insights of SOX6 expression in acute myeloid leukemia.0
363694282023MiR-19b-3p Inhibits Hypoxia-Ischemia Encephalopathy by Inhibiting SOX6 Expression via Activating Wnt/β-catenin Pathway.2
367053032023Circ_0001498 contributes to lipopolysaccharide-induced lung cell apoptosis and inflammation in sepsis-related acute lung injury via upregulating SOX6 by interacting with miR-574-5p.3
344110292022SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.1
353738602022An Osteoporosis Susceptibility Allele at 11p15 Regulates SOX6 Expression by Modulating TCF4 Chromatin Binding.1
354117162022Identification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer.2

Citation

Dessen P

SOX6 (SRY-box transcription factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46348/js/gene-fusions-explorer/welcome