Identity
HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
GluN1,MRD8,NDHMSD,NDHMSR,NMD-R1,NMDA1,NMDAR1,NR1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2902
MIM: 138249
HGNC: 4584
Ensembl: ENSG00000176884
Variants:
dbSNP: 2902
ClinVar: 2902
TCGA: ENSG00000176884
COSMIC: GRIN1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation | associated | PD | 23880023 | |
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA450403 | methamphetamine | Chemical | ClinicalAnnotation | associated | PD | 23880023 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35393335 | 2023 | Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B. | 2 |
| 36128677 | 2023 | Anti-N-Methyl-d-Aspartate Receptor Antibody Testing in First-Episode Psychosis: Universal or Targeted Testing. | 0 |
| 36543183 | 2023 | Autoimmune Encephalitis with Autoantibodies to NMDAR1 following Herpes Encephalitis in Children and Adolescents. | 0 |
| 37000222 | 2023 | Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening. | 1 |
| 37248111 | 2023 | Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling. | 3 |
| 37686003 | 2023 | Pluripotential GluN1 (NMDA NR1): Functional Significance in Cellular Nuclei in Pain/Nociception. | 1 |
| 37734923 | 2023 | GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. | 1 |
| 35393335 | 2023 | Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B. | 2 |
| 36128677 | 2023 | Anti-N-Methyl-d-Aspartate Receptor Antibody Testing in First-Episode Psychosis: Universal or Targeted Testing. | 0 |
| 36543183 | 2023 | Autoimmune Encephalitis with Autoantibodies to NMDAR1 following Herpes Encephalitis in Children and Adolescents. | 0 |
| 37000222 | 2023 | Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening. | 1 |
| 37248111 | 2023 | Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling. | 3 |
| 37686003 | 2023 | Pluripotential GluN1 (NMDA NR1): Functional Significance in Cellular Nuclei in Pain/Nociception. | 1 |
| 37734923 | 2023 | GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. | 1 |
| 34592350 | 2022 | The effect of human GRIN1 gene 5' functional region on gene expression regulation in vitro. | 1 |
Citation
Dessen P
GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46352/grin1-(glutamate-ionotropic-receptor-nmda-type-subunit-1)
