LIN9 (lin-9 DREAM MuvB core complex component)

2007-02-01  

Identity

HGNC
LOCATION
1q42.12
LOCUSID
ALIAS
BARA,BARPsv,Lin-9,TGS,TGS1,TGS2
FUSION GENES

Other Information

Locus ID:

NCBI: 286826
MIM: 609375
HGNC: 30830
Ensembl: ENSG00000183814

Variants:

dbSNP: 286826
ClinVar: 286826
TCGA: ENSG00000183814
COSMIC: LIN9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183814ENST00000328205Q5TKA1
ENSG00000183814ENST00000359525B1B047
ENSG00000183814ENST00000366808H0Y322
ENSG00000183814ENST00000460719H7C4T7
ENSG00000183814ENST00000481685C9J5J4

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Polo-like kinase mediated eventsREACTOMER-HSA-156711

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
320547692020LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.14
320547692020LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.14
280614492017Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.20
288079402017Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.18
280614492017Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.20
288079402017Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.18
241417692014A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c).26
244753162014LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.0
241417692014A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c).26
244753162014LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.0
233819442013A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.60
233819442013A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.60
218604172012Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.12
218604172012Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.12
203608442010Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest.26

Citation

Dessen P

LIN9 (lin-9 DREAM MuvB core complex component)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46365/lin9