TLR4 (toll like receptor 4)

2007-02-01  

Identity

HGNC
TLR4
LOCATION
9q33.1
LOCUSID
7099
ALIAS
ARMD10,CD284,TLR-4,TOLL

Other Information

Locus ID:

NCBI: 7099
MIM: 603030
HGNC: 11850
Ensembl: ENSG00000136869

Variants:

dbSNP: 7099
ClinVar: 7099
TCGA: ENSG00000136869
COSMIC: TLR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136869ENST00000355622O00206
ENSG00000136869ENST00000394487O00206
ENSG00000136869ENST00000472304A0A2R8Y7P4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Pathogenic Escherichia coli infectionKEGGko05130
Toll-like receptor signaling pathwayKEGGhsa04620
Pathogenic Escherichia coli infectionKEGGhsa05130
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
HIF-1 signaling pathwayKEGGhsa04066
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Toll-like receptor signalingKEGGhsa_M00686
Toll-like receptor signalingKEGGM00686
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR2/4)REACTOMER-HSA-5603041
MyD88 deficiency (TLR2/4)REACTOMER-HSA-5602498
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
IKK complex recruitment mediated by RIP1REACTOMER-HSA-937041
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
TRAF6 mediated induction of TAK1 complexREACTOMER-HSA-937072
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulationREACTOMER-HSA-975163
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133888799Organ TransplantationDiseaseClinicalAnnotationassociatedPK24820765
PA164713160Pertussis vaccinesChemicalClinicalAnnotationassociatedPD17699831, 22383676
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD24776844
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20136356
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD12742999
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD24776844
PA449692folic acidChemicalClinicalAnnotationassociatedPD20136356
PA450428methotrexateChemicalClinicalAnnotationassociatedPD20136356
PA451089pravastatinChemicalClinicalAnnotationassociatedPD12742999
PA451578tacrolimusChemicalClinicalAnnotationassociatedPK24820765

References

Pubmed IDYearTitleCitations
342462092024The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children.0
365855542024Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-κB pathway.3
371502512024LPS-TLR4 pathway exaggerates alcoholic hepatitis via provoking NETs formation.1
374627432024Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study.0
376716682024Homodimeric Granzyme A Opsonizes Mycobacterium tuberculosis and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14.1
376911122024Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.5
377181982024Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.0
378493362024Association of Toll-like receptor 4 gene polymorphism with multiple sclerosis in Iranian patients.0
378852792024Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2.2
379375212024Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.0
379770662024The expression of Nrf2 and TLRs in ear effusion in children with different types of otitis media and their relationship with inflammatory factors.0
379944152024Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments.0
380298332024Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19.0
381033652024P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer.0
381950882024Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent.0

Citation

Dessen P

TLR4 (toll like receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46368/tlr4-(toll-like-receptor-4)