HTR2A (5-hydroxytryptamine receptor 2A)

2007-02-01  

Identity

HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
5-HT2A,HTR2
FUSION GENES

Other Information

Locus ID:

NCBI: 3356
MIM: 182135
HGNC: 5293
Ensembl: ENSG00000102468

Variants:

dbSNP: 3356
ClinVar: 3356
TCGA: ENSG00000102468
COSMIC: HTR2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102468ENST00000378688P28223
ENSG00000102468ENST00000542664P28223
ENSG00000102468ENST00000543956P28223
ENSG00000102468ENST00000612998A0A087WZJ9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Gap junctionKEGGko04540
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Gap junctionKEGGhsa04540
Serotonergic synapseKEGGhsa04726
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD19365399
PA124CYP2C19GeneDataAnnotationassociated
PA128CYP2D6GeneDataAnnotationassociated
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD19193342
PA164712362AnalgesicsChemicalClinicalAnnotationassociatedPD25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD25096645
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociatedPD25096645
PA164713257Selective serotonin reuptake inhibitorsChemicalLiterature, MultilinkAnnotationassociated24930681
PA174GNAQGenePathwayassociated19741567
PA27093CYP1A2GeneDataAnnotationassociated
PA312SLC6A4GeneDataAnnotationassociated
PA443319Alzheimer DiseaseDiseaseClinicalAnnotationassociatedPD19494443
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD23859574
PA445048NauseaDiseaseClinicalAnnotationassociatedPD30221791
PA446051VomitingDiseaseClinicalAnnotationassociatedPD30221791
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD22006095
PA447198Autistic DisorderDiseaseClinicalAnnotation, MultilinkAnnotationassociatedPD19997080, 24753316
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD17671280, 19365399, 19590397, 23158458
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD27272046
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD19000940, 19193342, 32462699
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPD23859571
PA447268tardive dyskinesiaDiseaseClinicalAnnotationassociatedPD17688403
PA447278DepressionDiseaseClinicalAnnotation, DataAnnotationassociatedPD14514498, 17671280, 17697394, 18253134, 19590397
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotation, DataAnnotationassociatedPD11311507, 16205777, 16874005, 18253134, 19361869, 20075642, 22947179, 23733030, 25108775, 30221791
PA448687bupropionChemicalClinicalAnnotationassociatedPD22947179
PA449015citalopramChemicalClinicalAnnotationassociatedPD17671280, 19590397, 23158458, 30221791
PA449061clozapineChemicalLiterature, MultilinkAnnotationassociated24885933
PA449441efavirenzChemicalClinicalAnnotationassociatedPD23859571
PA449690fluvoxamineChemicalClinicalAnnotationassociatedPD16205777, 16874005, 19361869
PA450688olanzapineChemicalClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD19000940, 19193342, 19494443, 19636338, 24885933, 32462699
PA450801paroxetineChemicalClinicalAnnotationassociatedPD14514498, 17697394, 18253134, 19361869
PA451257risperidoneChemicalClinicalAnnotationassociatedPD19494443, 19997080, 23859574, 32462699
PA451566sumatriptanChemicalClinicalAnnotationassociatedPD25096645
PA451866venlafaxineChemicalClinicalAnnotationassociatedPD22006095
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD11311507, 18253134, 20075642, 23733030, 25108775
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD17688403, 27272046
PA452618opioidsChemicalClinicalAnnotationassociatedPD25096645

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
195069062009Candidate gene studies of ADHD: a meta-analytic review.263
182970542008Identification of a serotonin/glutamate receptor complex implicated in psychosis.235
152414352004Gene-environment interaction analysis of serotonin system markers with adolescent depression.151
188215652008Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.133
155506732004The human polyomavirus, JCV, uses serotonin receptors to infect cells.120
166424362006Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.112
166424362006Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.112
181982662008No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.111
189820042010Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.101

Citation

Dessen P

HTR2A (5-hydroxytryptamine receptor 2A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46384/htr2a-(5-hydroxytryptamine-receptor-2a)