Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3356
MIM: 182135
HGNC: 5293
Ensembl: ENSG00000102468
Variants:
dbSNP: 3356
ClinVar: 3356
TCGA: ENSG00000102468
COSMIC: HTR2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000102468 | ENST00000378688 | P28223 |
| ENSG00000102468 | ENST00000542664 | P28223 |
| ENSG00000102468 | ENST00000543956 | P28223 |
| ENSG00000102468 | ENST00000612998 | A0A087WZJ9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10074 | escitalopram | Chemical | ClinicalAnnotation | associated | PD | 19365399 | |
| PA124 | CYP2C19 | Gene | DataAnnotation | associated | |||
| PA128 | CYP2D6 | Gene | DataAnnotation | associated | |||
| PA128406954 | Weight gain | Disease | ClinicalAnnotation | associated | PD | 19193342 | |
| PA164712362 | Analgesics | Chemical | ClinicalAnnotation | associated | PD | 25096645 | |
| PA164712462 | Antiinflammatory agents, non-steroids | Chemical | ClinicalAnnotation | associated | PD | 25096645 | |
| PA164712741 | Ergot alkaloids | Chemical | ClinicalAnnotation | associated | PD | 25096645 | |
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | Literature, MultilinkAnnotation | associated | 24930681 | ||
| PA174 | GNAQ | Gene | Pathway | associated | 19741567 | ||
| PA27093 | CYP1A2 | Gene | DataAnnotation | associated | |||
| PA312 | SLC6A4 | Gene | DataAnnotation | associated | |||
| PA443319 | Alzheimer Disease | Disease | ClinicalAnnotation | associated | PD | 19494443 | |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PD | 23859574 | |
| PA445048 | Nausea | Disease | ClinicalAnnotation | associated | PD | 30221791 | |
| PA446051 | Vomiting | Disease | ClinicalAnnotation | associated | PD | 30221791 | |
| PA447196 | Anxiety Disorders | Disease | ClinicalAnnotation | associated | PD | 22006095 | |
| PA447198 | Autistic Disorder | Disease | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 19997080, 24753316 | |
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | 17671280, 19365399, 19590397, 23158458 | |
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation | associated | PD | 27272046 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 19000940, 19193342, 32462699 | |
| PA447230 | HIV Infections | Disease | ClinicalAnnotation | associated | PD | 23859571 | |
| PA447268 | tardive dyskinesia | Disease | ClinicalAnnotation | associated | PD | 17688403 | |
| PA447278 | Depression | Disease | ClinicalAnnotation, DataAnnotation | associated | PD | 14514498, 17671280, 17697394, 18253134, 19590397 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation, DataAnnotation | associated | PD | 11311507, 16205777, 16874005, 18253134, 19361869, 20075642, 22947179, 23733030, 25108775, 30221791 | |
| PA448687 | bupropion | Chemical | ClinicalAnnotation | associated | PD | 22947179 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 17671280, 19590397, 23158458, 30221791 | |
| PA449061 | clozapine | Chemical | Literature, MultilinkAnnotation | associated | 24885933 | ||
| PA449441 | efavirenz | Chemical | ClinicalAnnotation | associated | PD | 23859571 | |
| PA449690 | fluvoxamine | Chemical | ClinicalAnnotation | associated | PD | 16205777, 16874005, 19361869 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | PD | 19000940, 19193342, 19494443, 19636338, 24885933, 32462699 | |
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | PD | 14514498, 17697394, 18253134, 19361869 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 19494443, 19997080, 23859574, 32462699 | |
| PA451566 | sumatriptan | Chemical | ClinicalAnnotation | associated | PD | 25096645 | |
| PA451866 | venlafaxine | Chemical | ClinicalAnnotation | associated | PD | 22006095 | |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 11311507, 18253134, 20075642, 23733030, 25108775 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 17688403, 27272046 | |
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | PD | 25096645 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37703310 | 2024 | A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex. | 0 |
| 38565988 | 2024 | Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study. | 0 |
| 38657123 | 2024 | The Association Between the 5-Hydroxytryptamine Receptor 2A Gene Variants rs6311 and rs6313 and Obstructive Sleep Apnea in the Iranian Kurdish Population. | 0 |
| 38662111 | 2024 | Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint. | 0 |
| 38811567 | 2024 | G protein-specific mechanisms in the serotonin 5-HT(2A) receptor regulate psychosis-related effects and memory deficits. | 0 |
| 37703310 | 2024 | A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex. | 0 |
| 38565988 | 2024 | Interaction between HTR2A rs3125 and negative life events in suicide attempts among patients with major depressive disorder: a cross-sectional study. | 0 |
| 38657123 | 2024 | The Association Between the 5-Hydroxytryptamine Receptor 2A Gene Variants rs6311 and rs6313 and Obstructive Sleep Apnea in the Iranian Kurdish Population. | 0 |
| 38662111 | 2024 | Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint. | 0 |
| 38811567 | 2024 | G protein-specific mechanisms in the serotonin 5-HT(2A) receptor regulate psychosis-related effects and memory deficits. | 0 |
| 34789857 | 2023 | His452Tyr 5-HT(2A) polymorphism and intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. | 1 |
| 36639522 | 2023 | The contribution of the 5-hydroxytryptamine receptor 2 A gene polymorphisms rs6311 and rs6313 to Schizophrenia in Iran. | 2 |
| 36769290 | 2023 | Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. | 2 |
| 36889432 | 2023 | The crosstalk between 5-HT(2A)R and mGluR2 in schizophrenia. | 7 |
| 37019319 | 2023 | Association of GABRG3, GABRB3, HTR2A gene variants with autism spectrum disorder. | 1 |
Citation
Dessen P
HTR2A (5-hydroxytryptamine receptor 2A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46384/htr2a-(5-hydroxytryptamine-receptor-2a)
