PLA2G3 (phospholipase A2 group III)

2007-02-01  

Identity

HGNC
PLA2G3
LOCATION
22q12.2
LOCUSID
50487
ALIAS
GIII-SPLA2,SPLA2III,sPLA2-III

Other Information

Locus ID:

NCBI: 50487
MIM: 611651
HGNC: 17934
Ensembl: ENSG00000100078

Variants:

dbSNP: 50487
ClinVar: 50487
TCGA: ENSG00000100078
COSMIC: PLA2G3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100078ENST00000215885Q9NZ20

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340827972021Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization.7
340827972021Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization.7
271463842016Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.2
271463842016Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.2
259645852015Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer.6
259645852015Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer.6
245088012014Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.17
252300852014Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.44
252862282014Secreted phospholipases A2 in cancer: diverse mechanisms of action.34
245088012014Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.17
252300852014Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.44
252862282014Secreted phospholipases A2 in cancer: diverse mechanisms of action.34
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.7
200561782010Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.6
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.17

Citation

Dessen P

PLA2G3 (phospholipase A2 group III)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46392/pla2g3-(phospholipase-a2-group-iii)