FRAT1 (FRAT regulator of WNT signaling pathway 1)

2003-02-01

Identity

HGNC

FRAT1

LOCATION

10q24.1

LOCUSID

10023

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10023
MIM: 602503
HGNC: 3944
Ensembl: ENSG00000165879

Variants:

dbSNP: 10023
ClinVar: 10023
TCGA: ENSG00000165879
COSMIC: FRAT1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165879	ENST00000371021	Q92837

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Beta-catenin phosphorylation cascade	REACTOME	R-HSA-196299
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
Disassembly of the destruction complex and recruitment of AXIN to the membrane	REACTOME	R-HSA-4641262
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Wnt signaling pathway	KEGG	ko04310
Wnt signaling pathway	KEGG	hsa04310

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25387569	2015	The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.	4
25387569	2015	The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.	4
25922553	2015	Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.	8
25922553	2015	Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.	8
26178481	2015	The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.	10
27599661	2016	Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer.	2
27599661	2016	Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer.	2
27666874	2016	Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells.	7
27666874	2016	Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells.	7
34319909	2021	LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis.	7

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Citation

Dessen P

FRAT1 (FRAT regulator of WNT signaling pathway 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/464