LHX6 (LIM homeobox 6)

2007-02-01  

Identity

HGNC
LHX6
LOCATION
9q33.2
LOCUSID
26468
ALIAS
LHX6.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26468
MIM: 608215
HGNC: 21735
Ensembl: ENSG00000106852

Variants:

dbSNP: 26468
ClinVar: 26468
TCGA: ENSG00000106852
COSMIC: LHX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106852ENST00000340587Q9UPM6
ENSG00000106852ENST00000373754Q9UPM6
ENSG00000106852ENST00000373755Q9UPM6
ENSG00000106852ENST00000373755A0A024R852
ENSG00000106852ENST00000394319Q9UPM6
ENSG00000106852ENST00000464484H0YKH7
ENSG00000106852ENST00000482062H0YMY8
ENSG00000106852ENST00000541397Q9UPM6
ENSG00000106852ENST00000559895Q9UPM6
ENSG00000106852ENST00000560485H0YMH3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
167323322006LHX6 is a sensitive methylation marker in head and neck carcinomas.21
232295492013The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.13
241578762013LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer.13
283965962017Down-regulation of miR-214 reverses erlotinib resistance in non-small-cell lung cancer through up-regulating LHX6 expression.8
261297102015LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt/β-catenin signaling pathway.7
212404592011Epigenetic regulation of the potential tumor suppressor gene, hLHX6.1, in human cervical cancer.6
204288252010The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer.5
292263222018MiR-1290 promotes proliferation, migration, and invasion of glioma cells by targeting LHX6.5

Citation

Dessen P

LHX6 (LIM homeobox 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46414/lhx6-(lim-homeobox-6)