PRMT3 (protein arginine methyltransferase 3)

2007-02-01  

Identity

HGNC
PRMT3
LOCATION
11p15.1
LOCUSID
10196
ALIAS
HRMT1L3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10196
MIM: 603190
HGNC: 30163
Ensembl: ENSG00000185238

Variants:

dbSNP: 10196
ClinVar: 10196
TCGA: ENSG00000185238
COSMIC: PRMT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185238ENST00000330796E9PLF6
ENSG00000185238ENST00000331079O60678
ENSG00000185238ENST00000437750O60678
ENSG00000185238ENST00000525188E9PLF6
ENSG00000185238ENST00000526583E9PRB4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
Protein methylationREACTOMER-HSA-8876725

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364003112023Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers.1
366373512023PRMT3 regulates the progression of invasive micropapillary carcinoma of the breast.2
370244752023PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.9
379735602023PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma.6
364003112023Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers.1
366373512023PRMT3 regulates the progression of invasive micropapillary carcinoma of the breast.2
370244752023PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.9
379735602023PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma.6
334955662021PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling.6
339916502021Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.8
346471262021Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein l-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage.9
334955662021PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling.6
339916502021Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer.8
346471262021Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein l-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage.9
305304952019The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.17

Citation

Dessen P

PRMT3 (protein arginine methyltransferase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46415/js/welcome