ACOT8 (acyl-CoA thioesterase 8)

2013-12-01  

Identity

HGNC
ACOT8
LOCATION
20q13.12
LOCUSID
10005
ALIAS
HNAACTE,NAP1,PTE-1,PTE-2,PTE1,PTE2,hACTE-III,hTE

Other Information

Locus ID:

NCBI: 10005
MIM: 608123
HGNC: 15919
Ensembl: ENSG00000101473

Variants:

dbSNP: 10005
ClinVar: 10005
TCGA: ENSG00000101473
COSMIC: ACOT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101473ENST00000217455O14734
ENSG00000101473ENST00000426915Q9BR14
ENSG00000101473ENST00000457981H0Y698
ENSG00000101473ENST00000461272E9PJN0
ENSG00000101473ENST00000481938E9PMC4
ENSG00000101473ENST00000483141E9PRD4
ENSG00000101473ENST00000486165E9PIS4
ENSG00000101473ENST00000487205H7C5A7
ENSG00000101473ENST00000488679F6VBM3
ENSG00000101473ENST00000652771A0A494C0N6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Primary bile acid biosynthesisKEGGko00120
Primary bile acid biosynthesisKEGGhsa00120
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholateKEGGhsa_M00104
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholateKEGGM00104
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Peroxisomal lipid metabolismREACTOMER-HSA-390918
Beta-oxidation of pristanoyl-CoAREACTOMER-HSA-389887
Beta-oxidation of very long chain fatty acidsREACTOMER-HSA-390247
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolREACTOMER-HSA-193368
alpha-linolenic (omega3) and linoleic (omega6) acid metabolismREACTOMER-HSA-2046104
alpha-linolenic acid (ALA) metabolismREACTOMER-HSA-2046106

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
247889902014Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma.21
247889902014Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma.21
235402962013Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma.7
235402962013Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma.7
176240242007Nafamostat is hydrolysed by human liver cytosolic long-chain acyl-CoA hydrolase.4
176240242007Nafamostat is hydrolysed by human liver cytosolic long-chain acyl-CoA hydrolase.4
161412032005The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.42
163357992005Sterol Regulatory Element-Binding Protein-2 modulates human brain acyl-CoA hydrolase gene transcription.4
161412032005The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.42
163357992005Sterol Regulatory Element-Binding Protein-2 modulates human brain acyl-CoA hydrolase gene transcription.4

Citation

Dessen P

ACOT8 (acyl-CoA thioesterase 8)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/46420/acot8-(acyl-coa-thioesterase-8)