CD209 (CD209 molecule)

2007-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,hDC-SIGN

Other Information

Locus ID:

NCBI: 30835
MIM: 604672
HGNC: 1641
Ensembl: ENSG00000090659

Variants:

dbSNP: 30835
ClinVar: 30835
TCGA: ENSG00000090659
COSMIC: CD209

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090659ENST00000204801Q9NNX6
ENSG00000090659ENST00000315591Q9NNX6
ENSG00000090659ENST00000315599Q9NNX6
ENSG00000090659ENST00000354397Q9NNX6
ENSG00000090659ENST00000394161Q9NNX6
ENSG00000090659ENST00000394173X6RB12
ENSG00000090659ENST00000593660M0QZG5
ENSG00000090659ENST00000593821M0R0P0
ENSG00000090659ENST00000601256Q9NNX6
ENSG00000090659ENST00000601951Q9NNX6
ENSG00000090659ENST00000602261Q9NNX6

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Butyrophilin (BTN) family interactionsREACTOMER-HSA-8851680

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125158092003Mycobacteria target DC-SIGN to suppress dendritic cell function.317
120503982002C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.258
117399562001Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.217
174629202007C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.194
118590972002The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells.187
123529702002Diversity of receptors binding HIV on dendritic cell subsets.183
125158192003DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.182
127830862003Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses.182
197180302009Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.145
158801182005TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.134

Citation

Dessen P

CD209 (CD209 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46435/cd209-(cd209-molecule)