NR5A2 (nuclear receptor subfamily 5 group A member 2)

2007-02-01  

Identity

HGNC
NR5A2
LOCATION
1q32.1
LOCUSID
2494
ALIAS
B1F,B1F2,CPF,FTF,FTZ-F1,FTZ-F1beta,LRH-1,LRH1,hB1F-2

Other Information

Locus ID:

NCBI: 2494
MIM: 604453
HGNC: 7984
Ensembl: ENSG00000116833

Variants:

dbSNP: 2494
ClinVar: 2494
TCGA: ENSG00000116833
COSMIC: NR5A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116833ENST00000236914O00482
ENSG00000116833ENST00000236914F1D8R9
ENSG00000116833ENST00000367357H0Y328
ENSG00000116833ENST00000367362O00482
ENSG00000116833ENST00000447034H0Y7S7
ENSG00000116833ENST00000474307E9PQH2
ENSG00000116833ENST00000544748O00482

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in early pancreatic precursor cellsREACTOMER-HSA-210747

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382431142024Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos.1
384095062024Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition.2
382431142024Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos.1
384095062024Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition.2
367651312023Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.0
372850772023Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence.1
367651312023Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.0
372850772023Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence.1
358014072022LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance.6
363034472022MicroRNA-433-3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2.3
358014072022LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance.6
363034472022MicroRNA-433-3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2.3
329316512021Nuclear-mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer.10
330794292021Epithelial Nr5a2 heterozygosity cooperates with mutant Kras in the development of pancreatic cystic lesions.7
341291752021LRH-1 high expression in the ovarian granulosa cells of PCOS patients.1

Citation

Dessen P

NR5A2 (nuclear receptor subfamily 5 group A member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46438/nr5a2-(nuclear-receptor-subfamily-5-group-a-member-2)