EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha)

2007-02-01  

Identity

HGNC
LOCATION
14q23.3
LOCUSID
ALIAS
EIF-2,EIF-2A,EIF-2alpha,EIF2,EIF2A
FUSION GENES

Other Information

Locus ID:

NCBI: 1965
MIM: 603907
HGNC: 3265
Ensembl: ENSG00000134001

Variants:

dbSNP: 1965
ClinVar: 1965
TCGA: ENSG00000134001
COSMIC: EIF2S1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134001ENST00000256383P05198
ENSG00000134001ENST00000256383Q53XC0
ENSG00000134001ENST00000466499P05198
ENSG00000134001ENST00000466499Q53XC0
ENSG00000134001ENST00000555876H0YJS4
ENSG00000134001ENST00000557310G3V4T5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
ApoptosisKEGGko04210
Autophagy - animalKEGGhsa04140
ApoptosisKEGGhsa04210
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
RNA transportKEGGko03013
RNA transportKEGGhsa03013
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
Recycling of eIF2:GDPREACTOMER-HSA-72731
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
Gene ExpressionREACTOMER-HSA-74160
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
123702882002Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.225
180827452008Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease.177
168707032006Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.142
181950132008Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions.112
256217642015Translation of 5' leaders is pervasive in genes resistant to eIF2 repression.104
172106332007Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs.100
186042192008Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2.95
272118002016The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.91
126010122003P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.89
124998432002Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.87

Citation

Dessen P

EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46443/eif2s1-(eukaryotic-translation-initiation-factor-2-subunit-alpha)