EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha)

2007-02-01 Affiliation

Identity

HGNC

EIF2S1

LOCATION

14q23.3

LOCUSID

1965

ALIAS

EIF-2,EIF-2A,EIF-2alpha,EIF2,EIF2A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1965
MIM: 603907
HGNC: 3265
Ensembl: ENSG00000134001

Variants:

dbSNP: 1965
ClinVar: 1965
TCGA: ENSG00000134001
COSMIC: EIF2S1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134001	ENST00000256383	P05198
ENSG00000134001	ENST00000256383	Q53XC0
ENSG00000134001	ENST00000466499	P05198
ENSG00000134001	ENST00000466499	Q53XC0
ENSG00000134001	ENST00000555876	H0YJS4
ENSG00000134001	ENST00000557310	G3V4T5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
Apoptosis	KEGG	ko04210
Autophagy - animal	KEGG	hsa04140
Apoptosis	KEGG	hsa04210
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of the ternary complex, and subsequently, the 43S complex	REACTOME	R-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Translation initiation complex formation	REACTOME	R-HSA-72649
Ribosomal scanning and start codon recognition	REACTOME	R-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
Recycling of eIF2:GDP	REACTOME	R-HSA-72731
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
PERK regulates gene expression	REACTOME	R-HSA-381042
Gene Expression	REACTOME	R-HSA-74160
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38151653	2024	MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage.	0
38272235	2024	CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5.	0
38151653	2024	MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage.	0
38272235	2024	CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5.	0
37828427	2023	Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.	1
37828427	2023	Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.	1
34969763	2022	Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.	3
36438488	2022	C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.	5
34969763	2022	Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Profiling and Systematic Analysis.	3
36438488	2022	C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.	5
33946018	2021	Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis.	25
34052329	2021	PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.	11
34625748	2021	Higher-order phosphatase-substrate contacts terminate the integrated stress response.	10
33946018	2021	Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis.	25
34052329	2021	PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer.	11

Citation

Dessen P

EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46443/eif2s1-(eukaryotic-translation-initiation-factor-2-subunit-alpha)