GLP1R (glucagon like peptide 1 receptor)

2007-02-01  

Identity

HGNC
GLP1R
LOCATION
6p21.2
LOCUSID
2740
ALIAS
GLP-1,GLP-1-R,GLP-1R

Other Information

Locus ID:

NCBI: 2740
MIM: 138032
HGNC: 4324
Ensembl: ENSG00000112164

Variants:

dbSNP: 2740
ClinVar: 2740
TCGA: ENSG00000112164
COSMIC: GLP1R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112164ENST00000373256P43220

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Insulin secretionKEGGhsa04911
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748978sitagliptinChemicalClinicalAnnotationassociatedPD27160388
PA164749238exenatideChemicalVariantAnnotationassociatedPD30883264
PA165958346vildagliptinChemicalClinicalAnnotationassociatedPD27160388
PA165958364liraglutideChemicalClinicalAnnotationassociatedPD25991051
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotation, VariantAnnotationassociatedPD27160388, 30883264
PA445131ObesityDiseaseClinicalAnnotationassociatedPD25991051
PA445376Polycystic Ovary SyndromeDiseaseClinicalAnnotationassociatedPD25991051
PA447216SchizophreniaDiseaseClinicalAnnotationassociated24624910
PA449061clozapineChemicalClinicalAnnotationassociated24624910
PA450688olanzapineChemicalClinicalAnnotationassociated24624910

References

Pubmed IDYearTitleCitations
379782612024Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity.0
384440702024A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS.0
384619042024The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.2
386744152024Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts.0
388386422024Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.0
379782612024Integrated genetic and epigenetic analyses uncovered GLP1R association with metabolically healthy obesity.0
384440702024A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS.0
384619042024The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.2
386744152024Association between the GLP1R A316T Mutation and Adolescent Idiopathic Scoliosis in French Canadian and Italian Cohorts.0
388386422024Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.0
363736952023Glucagon-Like Peptide-1 (GLP-1) Rescue Diabetic Cardiac Dysfuntions in Human iPSC-Derived Cardiomyocytes.0
365926992023Pulsed electric fields stimulate microglial transmitter release of VEGF, IL-8 and GLP-1 and activate endothelial cells through paracrine signaling.1
366752172023GLP-1 Receptor Agonists in Non-Alcoholic Fatty Liver Disease: Current Evidence and Future Perspectives.26
367745422023Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells.5
367999402023Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies.8

Citation

Dessen P

GLP1R (glucagon like peptide 1 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46453/glp1r-(glucagon-like-peptide-1-receptor)