SYTL1 (synaptotagmin like 1)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
JFC1,SLP1
FUSION GENES

Other Information

Locus ID:

NCBI: 84958
MIM: 608042
HGNC: 15584
Ensembl: ENSG00000142765

Variants:

dbSNP: 84958
ClinVar: 84958
TCGA: ENSG00000142765
COSMIC: SYTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142765ENST00000318074Q8IYJ3
ENSG00000142765ENST00000473280Q5SSC6
ENSG00000142765ENST00000543823Q8IYJ3
ENSG00000142765ENST00000616558Q8IYJ3
ENSG00000142765ENST00000618673A0A087X1N4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379339092024WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.1
379339092024WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.1
361073842022ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.0
361073842022ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.0
270185962016MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.22
270185962016MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.22
224385812012Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.48
230822022012The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.1
224385812012Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.48
230822022012The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.1
195285392009Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.20
195285392009Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets.20
182667822008Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.41
182667822008Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.41
160046022005The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.17

Citation

Dessen P

SYTL1 (synaptotagmin like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46454/sytl1-(synaptotagmin-like-1)