CGB5 (chorionic gonadotropin subunit beta 5)

2007-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
CGB,HCG,hCGB

Other Information

Locus ID:

NCBI: 93659
MIM: 608825
HGNC: 16452
Ensembl: ENSG00000189052

Variants:

dbSNP: 93659
ClinVar: 93659
TCGA: ENSG00000189052
COSMIC: CGB5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189052ENST00000301408P0DN86
ENSG00000189052ENST00000301408A0A0F7RQP8

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
147157072004Transcriptional regulation of the human chorionic gonadotropin beta gene during villous trophoblast differentiation.18
125116032003A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene.16
254563632014Personalised chemotherapy based on tumour marker decline in poor prognosis germ-cell tumours (GETUG 13): a phase 3, multicentre, randomised trial.13
175102432007Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation.12
187828672008Chorionic gonadotropin beta-gene variants are associated with recurrent miscarriage in two European populations.12
209620202011Methylation allelic polymorphism (MAP) in chorionic gonadotropin beta5 (CGB5) and its association with pregnancy success.9
250641702014Association between altered placental human chorionic gonadotrophin (hCG) production and the occurrence of cryptorchidism: a retrospective study.9
118939042002The ISOBM TD-7 Workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives.8
235109932013MTA3 regulates CGB5 and Snail genes in trophoblast.8

Citation

Dessen P

CGB5 (chorionic gonadotropin subunit beta 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46460/cgb5-(chorionic-gonadotropin-subunit-beta-5)