UNC5B (unc-5 netrin receptor B)

2007-02-01  

Identity

HGNC
UNC5B
LOCATION
10q22.1
LOCUSID
219699
ALIAS
UNC5H2,p53RDL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 219699
MIM: 607870
HGNC: 12568
Ensembl: ENSG00000107731

Variants:

dbSNP: 219699
ClinVar: 219699
TCGA: ENSG00000107731
COSMIC: UNC5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107731ENST00000335350Q8IZJ1
ENSG00000107731ENST00000373192Q8IZJ1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381568652023Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.0
381568652023Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.0
359744112022Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.4
359744112022Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.4
333454422021The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.2
337065852021Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid cancer via sponging miR-129-5p.2
342396892021UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS-Mediated P53 Pathway.11
343810522021A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.12
344708262021Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity.7
333454422021The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.2
337065852021Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid cancer via sponging miR-129-5p.2
342396892021UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS-Mediated P53 Pathway.11
343810522021A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis.12
344708262021Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity.7
317690362020Netrin-1 and its receptor Unc5b as markers of periodontal disease.2

Citation

Dessen P

UNC5B (unc-5 netrin receptor B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46461/unc5b-(unc-5-netrin-receptor-b)