PPIB (peptidylprolyl isomerase B)

2007-02-01  

Identity

HGNC
PPIB
LOCATION
15q22.31
LOCUSID
5479
ALIAS
B,CYP-S1,CYPB,HEL-S-39,OI9,SCYLP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5479
MIM: 123841
HGNC: 9255
Ensembl: ENSG00000166794

Variants:

dbSNP: 5479
ClinVar: 5479
TCGA: ENSG00000166794
COSMIC: PPIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166794ENST00000300026P23284

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
316344942020Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication.49
321626542020Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.10
316344942020Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication.49
321626542020Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.10
309933522019Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations.5
310433532019Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer.10
309933522019Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations.5
310433532019Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer.10
304301482018A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis.2
304301482018A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis.2
282423922017Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX.8
283858902017Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.9
291469742017Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum.11
282423922017Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX.8
283858902017Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.9

Citation

Dessen P

PPIB (peptidylprolyl isomerase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46463/ppib-(peptidylprolyl-isomerase-b)