Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3133
MIM: 143010
HGNC: 4962
Ensembl: ENSG00000204592
Variants:
dbSNP: 3133
ClinVar: 3133
TCGA: ENSG00000204592
COSMIC: HLA-E
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000204592 | ENST00000376630 | P13747 |
| ENSG00000204592 | ENST00000376630 | A0A4E9D3W4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | ClinicalAnnotation | associated | PD | ||
| PA165107055 | certolizumab pegol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD | ||
| PA449515 | etanercept | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PD | ||
| PA452347 | glucocorticoids | Chemical | ClinicalAnnotation | associated | PD | ||
| PA452639 | infliximab | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36149610 | 2023 | Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer. | 4 |
| 36822912 | 2023 | HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease. | 1 |
| 37140910 | 2023 | Intracellular trafficking of HLA-E and its regulation. | 11 |
| 37390223 | 2023 | HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. | 3 |
| 37558657 | 2023 | High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation. | 2 |
| 37638008 | 2023 | The complex HLA-E-nonapeptide in Behçet disease. | 0 |
| 37901227 | 2023 | Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells. | 0 |
| 38007483 | 2023 | IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis. | 0 |
| 38064568 | 2023 | Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis. | 4 |
| 36149610 | 2023 | Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer. | 4 |
| 36822912 | 2023 | HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease. | 1 |
| 37140910 | 2023 | Intracellular trafficking of HLA-E and its regulation. | 11 |
| 37390223 | 2023 | HLA-E-restricted SARS-CoV-2-specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation. | 3 |
| 37558657 | 2023 | High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation. | 2 |
| 37638008 | 2023 | The complex HLA-E-nonapeptide in Behçet disease. | 0 |
Citation
Dessen P
HLA-E (major histocompatibility complex, class I, E)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46465/hla-e-(major-histocompatibility-complex-class-i-e)
