CRH (corticotropin releasing hormone)

2007-02-01  

Identity

HGNC
CRH
LOCATION
8q13.1
LOCUSID
1392
ALIAS
CRF,CRH1

Other Information

Locus ID:

NCBI: 1392
MIM: 122560
HGNC: 2355
Ensembl: ENSG00000147571

Variants:

dbSNP: 1392
ClinVar: 1392
TCGA: ENSG00000147571
COSMIC: CRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147571ENST00000276571P06850
ENSG00000147571ENST00000276571A0A0S2Z478

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Long-term depressionKEGGko04730
Long-term depressionKEGGhsa04730
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
163097882006Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): priming the placental clock.114
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
200471602010Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.68
227681752012CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α.58
145761872004Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells.48
162453032006CRH functions as a growth factor/cytokine in the skin.47
158833872005Role of peripheral corticotropin-releasing factor and urocortin II in intestinal inflammation and motility in terminal ileum.42
192584022009Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor.41
182954122008Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder.40
146758012003Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition.34

Citation

Dessen P

CRH (corticotropin releasing hormone)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46467/crh-(corticotropin-releasing-hormone)