ZFP42 (ZFP42 zinc finger protein)

2007-02-01 Affiliation

Identity

HGNC

ZFP42

LOCATION

4q35.2

LOCUSID

132625

ALIAS

REX-1,REX1,ZNF754,zfp-42

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 132625
MIM: 614572
HGNC: 30949
Ensembl: ENSG00000179059

Variants:

dbSNP: 132625
ClinVar: 132625
TCGA: ENSG00000179059
COSMIC: ZFP42

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179059	ENST00000326866	Q96MM3
ENSG00000179059	ENST00000509524	Q96MM3
ENSG00000179059	ENST00000618147	Q96MM3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15790780	2005	Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro.	64
23939908	2013	Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency.	34
18281244	2008	Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms.	31
16865673	2006	The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures.	23
17211834	2007	Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression.	15
20232320	2010	Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells.	5
30221575	2018	Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders.	4
27883224	2017	Basic Fibroblast Growth Factor Regulates REX1 Expression Via IL-6 In Stem Cells Isolated From Human Exfoliated Deciduous Teeth.	3
21446939	2011	Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.	2
31409905	2019	REX1 promotes EMT-induced cell metastasis by activating the JAK2/STAT3-signaling pathway by targeting SOCS1 in cervical cancer.	2

Citation

Dessen P

ZFP42 (ZFP42 zinc finger protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46472/zfp42-(zfp42-zinc-finger-protein)