SMOX (spermine oxidase)

2007-02-01  

Identity

HGNC
SMOX
LOCATION
20p13
LOCUSID
54498
ALIAS
C20orf16,PAO,PAO-1,PAO1,PAOH,PAOH1,SMO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54498
MIM: 615854
HGNC: 15862
Ensembl: ENSG00000088826

Variants:

dbSNP: 54498
ClinVar: 54498
TCGA: ENSG00000088826
COSMIC: SMOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088826ENST00000278795Q9NWM0
ENSG00000088826ENST00000305958Q9NWM0
ENSG00000088826ENST00000339123Q9NWM0
ENSG00000088826ENST00000346595Q9NWM0
ENSG00000088826ENST00000379460Q9NWM0
ENSG00000088826ENST00000457205Q5TE25
ENSG00000088826ENST00000621355Q9NWM0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
beta-Alanine metabolismKEGGko00410
Arginine and proline metabolismKEGGhsa00330
beta-Alanine metabolismKEGGhsa00410
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Interconversion of polyaminesREACTOMER-HSA-351200
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Amine Oxidase reactionsREACTOMER-HSA-140179
PAOs oxidise polyamines to aminesREACTOMER-HSA-141334

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
347677852022Protective Role of Spermidine in Colitis and Colon Carcinogenesis.31
347677852022Protective Role of Spermidine in Colitis and Colon Carcinogenesis.31
344658102021Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study.1
344658102021Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study.1
290935262017Spermine oxidase promotes bile canalicular lumen formation through acrolein production.9
291382592017Spectroscopic and calorimetric characterization of spermine oxidase and its association forms.3
290935262017Spermine oxidase promotes bile canalicular lumen formation through acrolein production.9
291382592017Spectroscopic and calorimetric characterization of spermine oxidase and its association forms.3
268953012016HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells.27
270415782016Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer.37
268953012016HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells.27
270415782016Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer.37
251743982015Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.63
251743982015Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.63
240251542014Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.46

Citation

Dessen P

SMOX (spermine oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46474/meetings/haematological-explorer/welcome