Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3952
MIM: 164160
HGNC: 6553
Ensembl: ENSG00000174697
Variants:
dbSNP: 3952
ClinVar: 3952
TCGA: ENSG00000174697
COSMIC: LEP
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000174697 | ENST00000308868 | P41159 |
| ENSG00000174697 | ENST00000308868 | A4D0Y8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA153906318 | Autism Spectrum Disorder | Disease | ClinicalAnnotation | associated | PD | 19873684, 21510767, 23799528, 26880915 | |
| PA447209 | Mood Disorders | Disease | ClinicalAnnotation | associated | PD | 19873684, 21510767, 23799528, 26880915 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 18681781 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PD | 18681781 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 19873684, 21510767, 23799528, 26880915 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 19873684, 21510767, 23799528, 26880915 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36583502 | 2024 | Leptin and energy balance: exploring Leptin's role in the regulation of energy intake and energy expenditure. | 6 |
| 37797814 | 2024 | Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin. | 1 |
| 37855224 | 2024 | The role of adiposity, adipokines and polymorphisms of leptin and adiponectin in myelodysplastic syndromes. | 0 |
| 37872379 | 2024 | Twenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study. | 0 |
| 37924810 | 2024 | The solution structure of human leptin reveals a conformational plasticity important for receptor recognition. | 0 |
| 37949710 | 2024 | The role of leptin in ischemic stroke and its subtypes: A Mendelian randomization study. | 0 |
| 38065428 | 2024 | Exploring the folding landscape of leptin: Insights into threading pathways. | 0 |
| 38090745 | 2024 | Leptin secreted by adipocytes promotes EMT transition and endometrial cancer progression via the JAK2/STAT3 signalling pathway. | 0 |
| 38091723 | 2024 | Whether serum leptin and insulin-like growth factor-1 are predictive biomarkers for post-stroke depression: A meta-analysis and systematic review. | 0 |
| 38095062 | 2024 | Leptin and adiposity measures from birth to later childhood: Findings from the Hyperglycemia and Adverse Pregnancy Outcomes Follow-Up Study. | 0 |
| 38206766 | 2024 | Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance. | 1 |
| 38256208 | 2024 | Molecular and Cellular Mechanisms Underlying the Cardiac Hypertrophic and Pro-Remodelling Effects of Leptin. | 0 |
| 38275620 | 2024 | Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth. | 0 |
| 38282611 | 2024 | Leptin promotes proliferation of human undifferentiated spermatogonia by activating the PI3K/AKT/mTOR pathway. | 0 |
| 38490517 | 2024 | Novel mechanisms involved in leptin sensitization in obesity. | 0 |
Citation
Dessen P
LEP (leptin)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46475/lep-(leptin)
