SLC2A4 (solute carrier family 2 member 4)

2007-02-01 Affiliation

Identity

HGNC

SLC2A4

LOCATION

17p13.1

LOCUSID

6517

ALIAS

GLUT4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6517
MIM: 138190
HGNC: 11009
Ensembl: ENSG00000181856

Variants:

dbSNP: 6517
ClinVar: 6517
TCGA: ENSG00000181856
COSMIC: SLC2A4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181856	ENST00000317370	P14672
ENSG00000181856	ENST00000424875	F5H081
ENSG00000181856	ENST00000570783	I3L1S2
ENSG00000181856	ENST00000571308	I3L2R4
ENSG00000181856	ENST00000572485	P14672

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Insulin signaling pathway	KEGG	ko04910
Adipocytokine signaling pathway	KEGG	ko04920
Type II diabetes mellitus	KEGG	ko04930
Insulin signaling pathway	KEGG	hsa04910
Adipocytokine signaling pathway	KEGG	hsa04920
Type II diabetes mellitus	KEGG	hsa04930
FoxO signaling pathway	KEGG	hsa04068
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Facilitative Na+-independent glucose transporters	REACTOME	R-HSA-428790
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA33744	PRKAA1	Gene	Pathway	associated	22722338
PA33745	PRKAA2	Gene	Pathway	associated	22722338
PA33746	PRKAB1	Gene	Pathway	associated	22722338
PA33747	PRKAB2	Gene	Pathway	associated	22722338
PA33751	PRKAG1	Gene	Pathway	associated	22722338
PA33752	PRKAG2	Gene	Pathway	associated	22722338
PA33753	PRKAG3	Gene	Pathway	associated	22722338

References

Pubmed ID	Year	Title	Citations
38566151	2024	GLUT4 localisation with the plasma membrane is unaffected by an increase in plasma free fatty acid availability.	0
38566151	2024	GLUT4 localisation with the plasma membrane is unaffected by an increase in plasma free fatty acid availability.	0
37061122	2023	Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression.	8
37073948	2023	Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle.	3
37368137	2023	Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression.	2
37395213	2023	Talin1 regulates glucose metabolism and endometrial receptivity via GLUT-4 in patients with polycystic ovary syndrome and insulin resistance.	1
37731227	2023	The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL.	0
37791639	2023	GLUT4 dispersal at the plasma membrane of adipocytes: a super-resolved journey.	0
38126809	2023	Regulated dynamic subcellular GLUT4 localization revealed by proximal proteome mapping in human muscle cells.	0
38136609	2023	Phosphorylation of Syntaxin 4 by the Insulin Receptor Drives Exocytic SNARE Complex Formation to Deliver GLUT4 to the Cell Surface.	0
37061122	2023	Glucose transporter 4: Insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression.	8
37073948	2023	Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle.	3
37368137	2023	Effect of an acute long-duration exercise bout on skeletal muscle lipid droplet morphology, GLUT 4 protein, and perilipin protein expression.	2
37395213	2023	Talin1 regulates glucose metabolism and endometrial receptivity via GLUT-4 in patients with polycystic ovary syndrome and insulin resistance.	1
37731227	2023	The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL.	0

Citation

Dessen P

SLC2A4 (solute carrier family 2 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46491/slc2a4-(solute-carrier-family-2-member-4)