Identity
HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
B7-H,B7H1,PD-L1,PDCD1L1,PDCD1LG1,PDL1,hPD-L1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29126
MIM: 605402
HGNC: 17635
Ensembl: ENSG00000120217
Variants:
dbSNP: 29126
ClinVar: 29126
TCGA: ENSG00000120217
COSMIC: CD274
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000120217 | ENST00000381573 | Q9NZQ7 |
| ENSG00000120217 | ENST00000381577 | Q9NZQ7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166124615 | pembrolizumab | Chemical | LabelAnnotation, MultilinkAnnotation | associated | 26086854 | ||
| PA166129522 | nivolumab | Chemical | LabelAnnotation, MultilinkAnnotation | associated | 26086854 | ||
| PA166129523 | atezolizumab | Chemical | LabelAnnotation | associated | |||
| PA166157522 | rs113488022 | Variant | LabelAnnotation | associated | |||
| PA166169875 | avelumab | Chemical | LabelAnnotation | associated | |||
| PA166169883 | durvalumab | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36650045 | 2024 | Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma. | 0 |
| 36855021 | 2024 | Influence of EGFR mutation status and PD-L1 expression in stage III unresectable non-small cell lung cancer treated with chemoradiation and consolidation durvalumab. | 2 |
| 37171482 | 2024 | Morphometric analysis of nuclear shape irregularity as a novel predictor of programmed death-ligand 1 expression in lung squamous cell carcinoma. | 0 |
| 37419794 | 2024 | The association between PD-1 / PD-L1 expression and clinicopathological features in sarcomatoid renal cell carcinoma. | 0 |
| 37553821 | 2024 | Apoptotic bodies inhibit inflammation by PDL1-PD1-mediated macrophage metabolic reprogramming. | 2 |
| 37614091 | 2024 | Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients. | 0 |
| 37639681 | 2024 | Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients. | 0 |
| 37688463 | 2024 | Elevated programmed cell death-1 protein/ligand (PD-1/PD-L1) and variants are associated with susceptibility to multiple myeloma: a case-control study in the Chinese cohort. | 0 |
| 37688767 | 2024 | Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis. | 1 |
| 37698736 | 2024 | N(6)-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m(6)A/PD-L1 manner. | 6 |
| 37776443 | 2024 | PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder. | 2 |
| 37792606 | 2024 | The levels of immunosuppressive checkpoint protein PD-L1 and tumor-infiltrating lymphocytes were integrated to reveal the glioma tumor microenvironment. | 0 |
| 37798754 | 2024 | Expression of B7-H3 and TIM-3 in gastric-type endocervical adenocarcinoma: prevalence, association with PD-L1 expression, and prognostic significance. | 0 |
| 37804164 | 2024 | Integrin α2 promotes immune escape in non-small-cell lung cancer by enhancing PD-L1 expression in exosomes to inhibit CD8 + T-cell activity. | 0 |
| 37937321 | 2024 | Expression of EGFR, PD-L1, and the mismatch repair proteins before and following therapy in malignant serous effusions with metastatic high-grade serous tubo-ovarian carcinoma. | 0 |
Citation
Dessen P
CD274 (CD274 molecule)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46492
