PLEK (pleckstrin)

2007-02-01  

Identity

HGNC
LOCATION
2p14
LOCUSID
ALIAS
P47
FUSION GENES

Other Information

Locus ID:

NCBI: 5341
MIM: 173570
HGNC: 9070
Ensembl: ENSG00000115956

Variants:

dbSNP: 5341
ClinVar: 5341
TCGA: ENSG00000115956
COSMIC: PLEK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115956ENST00000234313P08567

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378615002023Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis.1
378615002023Higher expression of PLEK and LY86 as the potential biomarker of carotid atherosclerosis.1
350875252021Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts.4
350875252021Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts.4
323375522020A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.7
323375522020A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.7
266806962015The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.6
266860602015Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.28
266806962015The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.6
266860602015Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.28
213938552011Crystallization and preliminary diffraction analysis of truncated human pleckstrin.1
213938552011Crystallization and preliminary diffraction analysis of truncated human pleckstrin.1
199446852010Novel role of pleckstrin homology domain of the Bcr-Abl protein: analysis of protein-protein and protein-lipid interactions.4
201907522010Multiple common variants for celiac disease influencing immune gene expression.471
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15

Citation

Dessen P

PLEK (pleckstrin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46495/css/js/humanGenome